Beneficial Microbes and Gastrointestinal Microbiota 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1325

Special Issue Editor


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Guest Editor
Food Research & Innovation Centre, College of Science, Engineering and Health, RMIT University, Melbourne, Australia
Interests: gut microbiome; probiotics and prebiotics; fermented foods; food safety; metabolomics; intestinal and respiratory infections and antimicrobials
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of the Special Issue “Beneficial Microbes and Gastrointestinal Microbiota”(https://www.mdpi.com/journal/microorganisms/special_issues/beneficial_microbes_gastrointestinal_microbiota).

Human gut epithelial surfaces are colonized and safeguarded by tremendous numbers of microorganisms, known as gastrointestinal microflora, which are crucial for forming and balancing complex microbial ecosystems. These diverse microorganisms, especially beneficial microbes, are essential for the gastrointestinal health and immunity of the hosts. However, factors such as malnutrition, immunodeficiency, and antibiotic therapy can induce dysbiosis of the gut microbial ecosystem, further inducing or leading to the deterioration of intestinal disorders and diseases, such as antibiotic-associated diarrhea, inflammatory bowel disease, ulcerative colitis, and even colorectal cancer. Over the last decade, we have witnessed spectacular research progress in identifying the functional roles of probiotics in human gastrointestinal health and applying probiotics for restoring homeostatic gut microbiota.

This Special Issue entitled “Beneficial Microbes and Gastrointestinal Microbiota” aims to present the most recent and cutting-edge research on all aspects relevant to the connection and interactions between probiotics, the gut microbiome, and intestinal health. We kindly invite the research community to submit original articles that provide novel insights into topics including, but not limited to, the following:

  • Probiotics and postbiotics in modulating the gastrointestinal microbiota and immunity;
  • Establishment and effectiveness of functional foods containing bioactive probiotic strains;
  • Novel efficient pro-commensal strategies to improve gastrointestinal health;
  • Metabolic and biofunctional enhancement of beneficial microbes;
  • Bacterial consortium for restoration of gut intestinal microbiota and treatment of enteric diseases.

Prof. Dr. Harsharn Gill
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • gut microbiome
  • gastrointestinal health
  • intestinal dysbiosis
  • enteric diseases
  • pro-commensal strategy
  • bacterial consortium.

Published Papers (2 papers)

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Research

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15 pages, 2252 KiB  
Article
Characterization of Probiotic Properties and Whole-Genome Analysis of Lactobacillus johnsonii N5 and N7 Isolated from Swine
by Kun Wang, Yu Wang, Lifang Gu, Jinyan Yu, Qianwen Liu, Ruiqi Zhang, Guixin Liang, Huan Chen, Fang Gu, Haoyu Liu, Xin’an Jiao and Yunzeng Zhang
Microorganisms 2024, 12(4), 672; https://doi.org/10.3390/microorganisms12040672 - 28 Mar 2024
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Abstract
In our previous microbiome profiling analysis, Lactobacillus (L.) johnsonii was suggested to contribute to resistance against chronic heat stress-induced diarrhea in weaned piglets. Forty-nine L. johnsonii strains were isolated from these heat stress-resistant piglets, and their probiotic properties were assessed. Strains [...] Read more.
In our previous microbiome profiling analysis, Lactobacillus (L.) johnsonii was suggested to contribute to resistance against chronic heat stress-induced diarrhea in weaned piglets. Forty-nine L. johnsonii strains were isolated from these heat stress-resistant piglets, and their probiotic properties were assessed. Strains N5 and N7 exhibited a high survival rate in acidic and bile environments, along with an antagonistic effect against Salmonella. To identify genes potentially involved in these observed probiotic properties, the complete genome sequences of N5 and N7 were determined using a combination of Illumina and nanopore sequencing. The genomes of strains N5 and N7 were found to be highly conserved, with two N5-specific and four N7-specific genes identified. Multiple genes involved in gastrointestinal environment adaptation and probiotic properties, including acidic and bile stress tolerance, anti-inflammation, CAZymes, and utilization and biosynthesis of carbohydrate compounds, were identified in both genomes. Comparative genome analysis of the two genomes and 17 available complete L. johnsonii genomes revealed 101 genes specifically harbored by strains N5 and N7, several of which were implicated in potential probiotic properties. Overall, this study provides novel insights into the genetic basis of niche adaptation and probiotic properties, as well as the genome diversity of L. johnsonii. Full article
(This article belongs to the Special Issue Beneficial Microbes and Gastrointestinal Microbiota 2.0)
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Review

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13 pages, 857 KiB  
Review
Transmission and Persistence of Infant Gut-Associated Bifidobacteria
by Margaret A. Hilliard and David A. Sela
Microorganisms 2024, 12(5), 879; https://doi.org/10.3390/microorganisms12050879 (registering DOI) - 27 Apr 2024
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Abstract
Bifidobacterium infantis are the primary colonizers of the infant gut, yet scientific research addressing the transmission of the genus Bifidobacterium to infants remains incomplete. This review examines microbial reservoirs of infant-type Bifidobacterium that potentially contribute to infant gut colonization. Accordingly, strain inheritance from [...] Read more.
Bifidobacterium infantis are the primary colonizers of the infant gut, yet scientific research addressing the transmission of the genus Bifidobacterium to infants remains incomplete. This review examines microbial reservoirs of infant-type Bifidobacterium that potentially contribute to infant gut colonization. Accordingly, strain inheritance from mother to infant via the fecal-oral route is likely contingent on the bifidobacterial strain and phenotype, whereas transmission via the vaginal microbiota may be restricted to Bifidobacterium breve. Additional reservoirs include breastmilk, horizontal transfer from the environment, and potentially in utero transfer. Given that diet is a strong predictor of Bifidobacterium colonization in early life and the absence of Bifidobacterium is observed regardless of breastfeeding, it is likely that additional factors are responsible for bifidobacterial colonization early in life. Full article
(This article belongs to the Special Issue Beneficial Microbes and Gastrointestinal Microbiota 2.0)
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