Oral Biofilms, 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 565

Special Issue Editor


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Guest Editor
School of Medicine, New York Medical College, Valhalla, NY 10595, USA
Interests: biofilm development and cell dispersion; COPD exacerbation; anti-microbial agent discovery; oral and systemic health linkage
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Special Issue Information

Dear Colleagues,

Microbial species are present in nature either as planktonic cells or incorporated into biofilms. Biofilms evolve from the planktonic state and are characterized as dense micro-communities that grow on inert surfaces and encapsulate themselves with secreted polymers. When organisms form a biofilm, they are able to adapt to environmental change by altering their gene expression patterns. The biofilm structure and related changes in gene expression can protect the microbes from disinfectant agents or antibiotics. The resultant biofilm can pose a serious public health issue. The physical nature of biofilms and the survival mechanisms they possess, whether phenotypic adaptability or genetic resistance, leave them impervious to antibiotic treatment. Given the lack of response to traditional antimicrobial therapy, biofilm infections currently pose a great challenge to the world of medicine.

The majority of oral microbes are commensal organisms. Those that are pathogenic microbes can result in oral infections and in some cases can initiate systemic diseases. This Special Issue focused on oral biofilms will address (1) the development and life cycle of oral biofilms; (2) innovative approaches to studying oral biofilms; and (3) methods to control the pathogenesis associated with biofilms.

Prof. Dr. Zvi Loewy
Guest Editor

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Keywords

  • oral biofilms
  • biofilm infections
  • antibiotic treatment
  • pathogenesis

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Published Papers (1 paper)

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Research

18 pages, 2821 KB  
Article
Microbiome Profiling of Biofilms Formed on d-PTFE Membranes Used in Guided Bone Regeneration
by Bojana Mohar Vitezić, Barbara Franović, Ira Renko, Davor Kuiš, Gabrijela Begić, Marko Blašković, Dragana Gabrić, Marina Nikolić, Tamara Šoić Vranić, Diana Veljanovska and Olga Cvijanović Peloza
Microorganisms 2025, 13(11), 2478; https://doi.org/10.3390/microorganisms13112478 - 30 Oct 2025
Viewed by 358
Abstract
In guided bone regeneration (GBR) procedures, d-PTFE membranes are often used as a barrier to promote alveolar ridge regeneration. The aim of this randomized clinical trial was to examine the microbial diversity and structure of biofilms on two types of d-PTFE membranes, Permamem [...] Read more.
In guided bone regeneration (GBR) procedures, d-PTFE membranes are often used as a barrier to promote alveolar ridge regeneration. The aim of this randomized clinical trial was to examine the microbial diversity and structure of biofilms on two types of d-PTFE membranes, Permamem® and Cytoplast™, over four-week oral cavity exposure periods. Bacterial biofilm analysis was performed using 16S rRNA next-generation sequencing (NGS) on 36 samples (20 Permamem® and 16 Cytoplast™). The results showed significant differences in the microbial profiles: Cytoplast™ membranes showed reduced microbial diversity and an enhanced proportion of pathobionts like Selenomonas, Segatella, Fusobacterium and Parvimonas, which are associated with periodontal and peri-implant diseases and alveolar bone loss. Permamem® membranes promoted colonization by bacteria associated with healthy oral conditions, such as the genera Streptococcus, Kingella and Corynebacterium. Overall, our results showed that Cytoplast™ membranes generate a specific type of biofilm, leading to reduction in health-related bacterial species and facilitating growth conditions for dysbiosis shift. Further research and patient follow-ups are essential to thoroughly evaluate the clinical implications of different d-PTFE membranes used in guided bone regeneration. Full article
(This article belongs to the Special Issue Oral Biofilms, 2nd Edition)
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