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Microorganisms
Special Issues
The Role of Microorganism in Gestational Diabetes Mellitus
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The Role of Microorganism in Gestational Diabetes Mellitus

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (30 December 2021) | Viewed by 3655

Special Issue Editors

Dr. Zohar Nachum

E-Mail Website
Guest Editor
1. Department of Obstetrics and Gynecology, Emek Medical Center, Afula 1834111, Israel
2. Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 3200003, Israel
Interests: maternal; fetal; medicine; diabetes in pregnancy; microbiome
Special Issues, Collections and Topics in MDPI journals
Dr. Enav Yefet

E-Mail Website
Guest Editor
1. Department of Obstetrics & Gynecology, Baruch Padeh Medical Center Poriya, Tiberias 1410000, Israel
2. Azrieli Faculty of Medicine, Bar Ilan University, Safed 1310000, Israel
Interests: maternal; fetal medicine; diabetes; microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gestational diabetes mellitus (GDM) complicates 4–12% of pregnancies and is considered one of the most prevalent pregnancy complications. The severe maternal and neonatal morbidities associated with uncontrolled GDM underscores the importance of adequate glucose control during pregnancy.

In recent years, the role of the intestinal microbiome in the context of metabolic diseases, particularly in glucose and insulin metabolism, has attracted a lot of attention. In parallel, a growing body of evidence has shown that probiotic supplements improve glucose metabolism by increasing host insulin sensitivity, cholesterol metabolism, and having a beneficial effect on the immune system. More specifically, they have been shown to reduce fasting glucose and hemoglobin A1C levels in non-pregnant individuals with diabetes. The characteristics common to GDM and diabetes mellitus have raised questions regarding the metabolic effects of the microbiome and probiotic treatments in women with GDM.

The aim of this Special Issue is to provide a collection of articles that showcase the current research of “The Role of Microorganism in Gestational Diabetes Mellitus”. As Guest Editors of this Special Issue, we invite you to submit research articles, review articles, and short communications related to this topic.

Dr. Zohar Nachum
Dr. Enav Yefet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gestational diabetes mellitus
  • microbiome
  • glycemic control
  • glucose and insulin metabolism
  • obstetric complications
  • probiotics
  • lactobacilli
  • obesity
  • weight gain
  • fat metabolism

Published Papers (1 paper)

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Research

10 pages, 980 KiB  
Article
Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
by Palin Sililas, Lingling Huang, Chanisa Thonusin, Suchaya Luewan, Nipon Chattipakorn, Siriporn Chattipakorn and Theera Tongsong
Microorganisms 2021, 9(8), 1686; https://doi.org/10.3390/microorganisms9081686 - 08 Aug 2021
Cited by 15 | Viewed by 3096
Abstract
Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The [...] Read more.
Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). Methods: Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24–28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. Results: from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Conclusions: Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed. Full article
(This article belongs to the Special Issue The Role of Microorganism in Gestational Diabetes Mellitus)
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