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Microorganisms
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Stress Signaling in Pathogenic Fungi
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Stress Signaling in Pathogenic Fungi

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5130

Special Issue Editor

Dr. Jason M. Rauceo

E-Mail Website
Guest Editor
Department of Science, John Jay College of the City University of New York (CUNY), New York, NY 10019, USA
Interests: cellular and molecular mechanisms of environmental stress signaling; Candida; structure and function of cell wall adhesins

Special Issue Information

Dear Colleagues,

Fungi occupy diverse niches and frequently encounter challenges from host defenses, resident microflora, and fluctuations in environmental pH and osmolarity. Signaling pathways are critical for survival and adaptation. There is extensive information available regarding the molecular mechanisms underlying stress signaling pathways in benign yeasts. However, a comprehensive analysis of signaling pathways is still needed in pathogenic fungi.

The aim of this special issue is to better understand fungal stress signaling pathways with an emphasis on human pathogenic species. Manuscripts covering all aspects of stress signaling are welcome. Topics include, but are not limited to, functional divergence of conserved regulatory proteins (circuitry rewiring), the transcriptional networks underlying stress response signaling, and the functional activities of downstream stress-response effector genes.

I invite you to submit a research paper, review article, or short communication for this special issue.

Dr. Jason M. Rauceo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fungi
  • Cell Signaling
  • Proteomics
  • Transcriptome
  • Stress Response
  • Virulence

Published Papers (2 papers)

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Research

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11 pages, 2068 KiB  
Article
YPK9 and WHI2 Negatively Interact during Oxidative Stress
by Florenal Joseph, Darach Miller, Oleg V. Evgrafov and William J. Chirico
Microorganisms 2021, 9(12), 2584; https://doi.org/10.3390/microorganisms9122584 - 14 Dec 2021
Viewed by 2047
Abstract
Yeast PARK9 (YPK9) shares homology with human ATP13A2, which encodes a polyamine transporter implicated in juvenile forms of Parkinson’s disease. We used YPK9 to gain insight into how ATP13A2 affects cell growth and sensitivity to oxidative stress. Surprisingly, the YPK9 [...] Read more.
Yeast PARK9 (YPK9) shares homology with human ATP13A2, which encodes a polyamine transporter implicated in juvenile forms of Parkinson’s disease. We used YPK9 to gain insight into how ATP13A2 affects cell growth and sensitivity to oxidative stress. Surprisingly, the YPK9 deletion strain from the Saccharomyces cerevisiae deletion collection (YKO) in wildtype BY4741 (mating type a) grew faster and was more resistant to hydrogen peroxide than a commercial, putative parental BY4741 wildtype strain (BY4741COM). In contrast, deleting YPK9 from BY4741COM rendered it very sensitive to hydrogen peroxide, suggesting its background is different from that of the deletion collection. Whole-genome sequencing revealed that BY4741COM and BY4741COMypk9∆ contain a novel premature stop codon near the 3′ end of WHI2 (WHI2G1324T), whereas the collection’s YPK9 deletion strain contains WHI2, which encodes a 486 amino acid protein, Whi2p. Replacing full-length WHI2 with the sequence coding for the predicted truncation (Whi2pE442*) rendered strains more sensitive to hydrogen peroxide, whereas the converse replacement rendered them more resistant. The sequences of WHI2 in 20 randomly chosen strains from the collection encode the full-length protein, indicating that the putative parental BY4741 WHI2G1324T strain’s genetic background differs from that of the deletion collection. Examination of WHI2 sequences in several commonly used wildtype S. cerevisiae strains and isolates revealed other Whi2p truncations that might yield altered phenotypes. Together, these results demonstrate a novel premature stop codon in WHI2 that renders yeast sensitive to hydrogen peroxide; they also reveal a negative genetic interaction between WHI2 and YPK9 in the presence of hydrogen peroxide in the BY4741 background. Full article
(This article belongs to the Special Issue Stress Signaling in Pathogenic Fungi)
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Review

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10 pages, 1173 KiB  
Review
The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
by Marienela Y. Heredia and Jason M. Rauceo
Microorganisms 2021, 9(11), 2287; https://doi.org/10.3390/microorganisms9112287 - 3 Nov 2021
Cited by 2 | Viewed by 2476
Abstract
Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling, and mechanosensation. In addition, [...] Read more.
Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling, and mechanosensation. In addition, SPFH proteins are required for virulence in parasites. While mitochondrial functions of SPFH proteins are conserved in fungi, recent evidence has uncovered additional roles for SPFH proteins in filamentation and stress signaling. Inhibitors that target SPFH proteins have been successfully used in cancer and inflammation treatment. Thus, SPFH proteins may serve as a potential target for novel antifungal drug development. This review article surveys SPFH function in various fungal species with a special focus on the most common human fungal pathogen, Candida albicans. Full article
(This article belongs to the Special Issue Stress Signaling in Pathogenic Fungi)
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