Host-Intracellular Bacteria Interactions
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 8454
Special Issue Editor
Special Issue Information
Dear Colleagues,
A fundamental step for the survival and replication of intravacuolar bacterial pathogens is the establishment of a replicative niche inside host cells. This is achieved by secreting bacterial effector proteins in the cytoplasm of the infected cells by a specialised secretion systems. Bacterial effector proteins interact with eukaryotic proteins and genes to manipulate host signalling pathways, thus allowing the host degradative pathway to escape and the nutrients required for intracellular replication of bacteria to converge. Understanding the bacterial–host interactions that regulate these processes is therefore of prime importance to counter bacterial infections and identify candidate targets for the development of host-targeted antimicrobials, as an alternative to antibiotics. Similarly, bacterial endosymbionts also colonize their hosts by means of secreted effectors that modify cellular processes to make a cosy replicative niche and to facilitate transmission and spreading. The need to know more about symbiotic effectors is great since they help make the process of infection easier and therefore help to better control infectious diseases.
Dr. Damien F. Meyer
Guest Editor
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Keywords
- secretion systems
- effectors
- intracellular bacteria
- interaction
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