Stem-Cell Based 3D Organoids; Application in Microbial Pathogenesis and Advances
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 130
Special Issue Editor
Interests: viral hepatitis; new emerging pathogen; acute hepatitis of unknown etiology; pathogenesis; animal model
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Three-dimensional (3D) organoids are considered a preclinical model for studying human disease. These organoids are developed from stem cells that can expand in vitro and they physiologically mimic the internal organs. Recent approaches enable the development of organoids from different organs such as the colon, intestine, kidney, pancreas, endometrium, etc. These organoids can be used for studying microbial pathogenesis and identification of the pathways associated with the disease pathogenesis. Application of gene editing technologies such as CRISPR/Cas9 in the organoid model helps to identify human disease and develop a cancer model in vitro. Besides, 3D organoids and 2D enteriod-derived monolayers (EDMs) can be used for screening drugs, anti-cancer therapies, nutritional supplements, and other potential therapeutic candidates that could be beneficial for personalized medicine.
The Special Issue entitled "Stem-Cell Based 3D Organoids; Application in Microbial Pathogenesis and Advances" aims to present recent research on mysteries of use of stem-cell based model for studying host-pathogen interaction and testing potential therapeutic candidates.
Dr. Ibrahim M. Sayed
Guest Editor
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Keywords
- 3D organoids and enteriod derived monolayer
- stem cells and primary epithelial cells
- gene editing and CRISPR-Cas systems
- in vitro model system
- host-pathogen interactions
- evaluation theraputic candidates
