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Microorganisms
Special Issues
Antimicrobial Resistance: Challenges and Innovative Solutions, 2nd Edition
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Antimicrobial Resistance: Challenges and Innovative Solutions, 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 354

Special Issue Editor

Dr. Dimitris C. Chatzopoulos

E-Mail Website
Guest Editor
Faculty of Public and One Health, University of Thessaly, 43100 Karditsa, Greece
Interests: zoonoses; antimicrobial resistance; molecular epidemiology; biofilm production; emerging pathogens
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Antimicrobial Resistance: Challenges and Innovative Solutions”.

Microorganisms invites researchers to contribute to a Special Issue addressing the critical issue of antimicrobial resistance. This Special Issue aims to explore the challenges posed by antimicrobial resistance and highlight innovative solutions to combat this global threat.

We welcome original research, reviews, and perspectives on various aspects of antimicrobial resistance, including mechanisms of resistance, epidemiology, and the impact on human and animal health. Contributions investigating novel therapeutic approaches such as combination therapies, alternative antimicrobial agents, and drug repurposing are encouraged.

Additionally, we invite the submission of studies on antimicrobial stewardship programs, infection control strategies, and surveillance systems aimed at monitoring and preventing the spread of resistant pathogens. Research on the development of diagnostic tools, vaccines, and strategies to mitigate the emergence and dissemination of resistance genes will also be highly valued.

Dr. Dimitris C. Chatzopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • mechanisms of resistance
  • therapeutic approaches
  • antimicrobial stewardship
  • infection control
  • public health

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Published Papers (1 paper)

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Research

21 pages, 1015 KB  
Article
Combating Foodborne MRSA: Identification and Silver Nanoparticle-Based Antibacterial Strategies with Antibiotic Synergy and Resistance Evolution Assessment
by Adil Abalkhail and Eman Marzouk
Microorganisms 2025, 13(10), 2393; https://doi.org/10.3390/microorganisms13102393 - 18 Oct 2025
Viewed by 289
Abstract
Ready-to-eat (RTE) foods can carry antimicrobial-resistant pathogens; however, few studies link real-world surveillance to practical interventions. This study addressed this gap by estimating the prevalence of Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) in ready-to-eat foods from Al-Qassim and [...] Read more.
Ready-to-eat (RTE) foods can carry antimicrobial-resistant pathogens; however, few studies link real-world surveillance to practical interventions. This study addressed this gap by estimating the prevalence of Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) in ready-to-eat foods from Al-Qassim and evaluating a rapid, orthogonal confirmation workflow (culture → MALDI-TOF MS → Vitek 2 → mecA/mecC PCR). The in vitro activity of citrate-stabilized silver nanoparticles (AgNPs) against food-derived MRSA was quantified, and synergy with oxacillin (primary) and ciprofloxacin (secondary) was examined. Silver-susceptibility stability was assessed over 20 days of sub-MIC serial passage, with attention to whether β-lactam co-exposure constrained drift. We surveyed 149 RTE products and paired the confirmation workflow with mechanistic tests of AgNPs as antibiotic adjuvants. S. aureus was recovered from 24.2% of products and MRSA from 6.7%, with higher recovery from animal-source matrices and street-vendor outlets. MALDI-TOF MS provided rapid species confirmation and revealed two reproducible low-mass peaks (m/z 3990 and 4125) associated with MRSA, supporting spectral triage pending molecular confirmation. Antimicrobial susceptibility testing showed the expected β-lactam split (MRSA oxacillin/cefoxitin non-susceptible; MSSA oxacillin-susceptible but largely penicillin-resistant), with last-line agents retained. Citrate-stabilized AgNPs displayed consistent potency against food-derived MRSA (MIC 8–32 µg/mL; MIC50 16; MIC90 32) and were predominantly bactericidal (MBC/MIC ≤ 4 in 90%). Checkerboards demonstrated frequent AgNP–oxacillin synergy (median fractional inhibitory concentration index [FICI] 0.37; 4–16-fold oxacillin MIC reductions) and additive-to-synergistic effects with ciprofloxacin (median FICI 0.63), translating time–kill assays into rapid, sustained bactericidal activity without antagonism. During sub-MIC evolution, silver MICs rose modestly (median two-fold) and often regressed off drug; oxacillin co-exposure limited drift. RTE foods therefore represent credible MRSA exposure routes. Integrating MALDI-assisted triage with automated AST enables scalable surveillance, and standardized AgNP formulations emerge as promising β-lactam adjuvants—pending in situ efficacy, safety, and residue evaluation. Full article
(This article belongs to the Special Issue Antimicrobial Resistance: Challenges and Innovative Solutions, 2nd Edition)
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