Advancement in Enterotoxigenic Escherichia coli (ETEC) Vaccines
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 61
Special Issue Editor
Special Issue Information
Dear Colleagues,
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children in developing countries and in travellers to these regions. It is also a major cause of diarrhea in piglets and calves. Intensive ongoing efforts aim to develop safe and effective ETEC vaccines for use in travellers as well as in children in endemic areas. Several promising ETEC candidate vaccines have reached the stage of Phase 1-2b clinical trials in humans, with promising results. Efforts to improve ETEC vaccines for use in livestock are also in progress. This Special Issue will address the following aims:
- Provide an update of the epidemiology of ETEC disease in populations in developing countries and in travellers to these regions as a background for ETEC vaccine development.
- Present different vaccine candidates, including new putative vaccine antigens, as well as promising adjuvants.
- Explore different approaches to develop combined enteric vaccines, e.g., ETEC and Shigella.
- Describe recent, ongoing and planned clinical trials of ETEC vaccines in target population (travellers to, and children and adults in ETEC endemic areas).
- Outline the issue of ETEC disease in livestock and efforts to develop improved ETEC vaccines.
Dr. Ann-Mari Svennerholm
Guest Editor
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Keywords
- ETEC vaccine candidates
- protective antigens
- adjuvants
- clinical trial phase 1-2b
- ETEC epidemiology
- travellers
- children in LMIC
- ETEC in animals
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