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Journals
Microorganisms
Special Issues
Host–Microbiota Interaction in Metabolic Diseases
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Host–Microbiota Interaction in Metabolic Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 110

Special Issue Editors

Dr. Zhipeng Li

E-Mail Website
Guest Editor
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China
Interests: bioactive components; host–gut microbiota interaction; metabolic diseases
Dr. Weiwei He

E-Mail Website
Guest Editor
State Key Laboratory of Food Science and Resources, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang, China
Interests: intestinal microorganisms; metabolites

Special Issue Information

Dear Colleagues,

The gut microbiota plays a pivotal role in regulating host metabolism and influencing the progression of metabolic diseases. Recent studies have uncovered intricate interactions between gut microbes, host metabolic pathways, and immune responses, shedding light on their contributions to conditions such as obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). These discoveries not only enhance our understanding of disease pathogenesis but also pave the way for novel microbiota-targeted therapeutic strategies.

This Special Issue invites cutting-edge research and comprehensive reviews focusing on the role of gut microbiota in metabolic health. Topics of interest include the following:

  1. The role of gut microbes in the development and progression of metabolic diseases such as obesity, diabetes, and NAFLD.
  2. Mechanisms by which gut microbiota regulate adipocyte differentiation, energy metabolism, and inflammatory responses through the gut–adipose tissue axis.
  3. Application of data-driven analytical approaches and multi-omics techniques in systems biology to uncover potential gut microbes and their mechanisms influencing host metabolism.
  4. The mediating role of gut microbiota in the effects of food components, traditional Chinese medicine, pharmacological agents, and other interventions on metabolic diseases.
  5. Investigation of microbial metabolites mediating the regulatory effects of gut microbes on host metabolism and their underlying mechanisms

Dr. Zhipeng Li
Dr. Weiwei He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • metabolic disease
  • obesity
  • diabetes
  • non-alcoholic fatty liver disease
  • multi-omics
  • microbial metabolites

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Published Papers (1 paper)

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Research

18 pages, 2700 KB  
Article
Clostridium butyricum Supplementation Reduces Diarrhea in Preweaning Calves by Modulating Fecal Short-Chain Fatty Acids and Gut Microbiota
by Peiyun Gao, Shaoyang Pang, Qianqian Wang, Yaqin Tang, Qiuyan Li, Wenju Zhang, Cunxi Nie, Xiaoling Ma and Junli Niu
Microorganisms 2025, 13(9), 1993; https://doi.org/10.3390/microorganisms13091993 - 27 Aug 2025
Abstract
This study investigated the effects of dietary supplementation with varying doses of Clostridium butyricum (C. butyricum) on growth performance, diarrhea incidence, serum biochemical parameters, fecal short-chain fatty acids (SCFAs), and fecal microbiota in preweaning Holstein calves. Forty healthy newborn Holstein heifer [...] Read more.
This study investigated the effects of dietary supplementation with varying doses of Clostridium butyricum (C. butyricum) on growth performance, diarrhea incidence, serum biochemical parameters, fecal short-chain fatty acids (SCFAs), and fecal microbiota in preweaning Holstein calves. Forty healthy newborn Holstein heifer calves with comparable birth weights were randomly assigned to four groups (control, 1 g/d supplementation, 3 g/d supplementation, and 5 g/d supplementation) for a 60-day trial. Growth parameters, diarrhea incidence, serum immunoglobulins (IgA, IgG, IgM), cytokines (IL-1β, TNF-α), antioxidant indicators (T-AOC, MDA), fecal short-chain fatty acids (SCFAs), and microbial composition were measured to evaluate the effects of C. butyricum. The results indicated that calves in the 5 g/d group exhibited a significantly higher average daily gain (ADG) compared with the control group (804.67 vs. 701.67 g/d, p < 0.05), with no significant differences in feed intake observed among groups (p > 0.05). During Days 22–42, the diarrhea incidence in the 5 g/d group was 7.74% lower than that in the control group (p < 0.05). This group exhibited significantly elevated serum IgM levels (Day 42, p < 0.05) and reduced IL-1β concentrations (Day 42, p < 0.05). Additionally, total antioxidant capacity (T-AOC) was significantly enhanced (Days 42 and 60, p < 0.05), while malondialdehyde (MDA) content was significantly decreased (Days 21 and 42, p < 0.05). At Day 42, fecal propionate and butyrate concentrations were significantly elevated in the 5 g/d group (p < 0.05), while the relative abundances of Bacteroides, Acidaminococcus, Bifidobacterium, Olsenella, Faecalitalea, and Ruminococcus were significantly increased (p < 0.05). The increase in these short-chain fatty acids and beneficial bacteria contributes to improved intestinal health and thus helps alleviate diarrhea. These findings indicate that supplementing preweaning calves’ milk with 5 g/d of C. butyricum significantly enhances growth performance and intestinal health. This provides evidence for the use of C. butyricum as a natural alternative to antibiotics in calf rearing. Full article
(This article belongs to the Special Issue Host–Microbiota Interaction in Metabolic Diseases)
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