Advances in Diet–Host–Gut Microbiome Interactions: Second Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 422

Special Issue Editor


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Guest Editor
1. Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China
2. Biostatistics Department, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
Interests: microbiome; microbial genomics; meta-omics; microbiome–host interaction; microbiome–diet interaction; food science
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Advances in Diet–Host–Gut Microbiome Interactions” (https://www.mdpi.com/journal/microorganisms/special_issues/MHG256OD7M).

The gut microbiome plays a vital role in influencing host health and disease by influencing digestion, nutrient absorption, metabolism, and immune function. Dietary components directly shape the composition and function of the gut microbiota, which in turn impacts various aspects of host physiology and susceptibility to diseases. There is growing interest in the role of functional foods, probiotics, prebiotics, and synbiotics in modulating gut microbiota composition and activity. In this context, studying the interactions among diet, the host, and the gut microbiome is essential to understanding the intricate balance between dietary intake, the gut microbiota, and overall health outcomes. Unraveling the complexities of these interactions offers new avenues for promoting health and preventing disease through personalized nutrition and microbiome-targeted interventions.

As the Guest Editor of this Special Issue, I would like to invite you to submit perspective articles, original research articles, review articles, and short communications on various aspects of new mechanism insights into interplays among the diet, gut microbiome, and host; innovations in methodologies and technologies for studying diet–host–microbiome interactions; and advances in personalized nutrition approaches targeting the gut microbiota for health promotion and disease prevention.

Dr. Yancong Zhang
Guest Editor

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Keywords

  • gut microbiome
  • diet
  • food
  • nutrition
  • dysbiosis
  • host–microbe interactions
  • microbial bioactivity
  • multi-omics
  • microbial therapy
  • personalized nutrition

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Published Papers (1 paper)

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Research

12 pages, 1057 KB  
Article
Colonisation of Newborn Piglets with a Mixture of Bacteroides Species Improves Their Gut Health and Performance
by Jitka Matiasovicova, Katerina Nechvatalova, Daniela Karasova, Alena Sebkova, Jan Matiasovic, Jiri Volf, Vladimir Babak and Ivan Rychlik
Microorganisms 2025, 13(10), 2356; https://doi.org/10.3390/microorganisms13102356 - 14 Oct 2025
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Abstract
Due to the low populations of Bacteroides sp. in the gut microbiota of sows compared to nursed piglets, sows may not represent an ideal source of Bacteroides sp. for newborn piglets. In this study, we therefore tested the effect of oral administration of [...] Read more.
Due to the low populations of Bacteroides sp. in the gut microbiota of sows compared to nursed piglets, sows may not represent an ideal source of Bacteroides sp. for newborn piglets. In this study, we therefore tested the effect of oral administration of a mixture of Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides xylanisolvens on the microbiota development of newborn piglets. Oral administration of such a mixture to piglets within 12 h after parturition did not result in any adverse effects. Sequencing of 16S rRNA showed that 4 days after administration, these species formed approx. 20% of total faecal microbiota and affected the development of gut microbiota in treated piglets. The treatment resulted in an increased abundance of Veillonella caviae, Fusobacterium gastrosuis, Dialister sp., Clostridium jeddahitimonense, C. cadaveris, Butyricicoccus pullicaecorum, Actinobacillus indolicus, A. minor, Streptococcus pasteurianus, S. parasuis, S. equinus, S. pluranimalium, S. thoraltensis and S. suis. On the other hand, administration of the Bacteroides mixture suppressed piglet colonisation by C. disporicum and multiple species from family Prevotellaceae. Bacteroides-treated piglets exhibited significantly higher body weight than untreated controls at 3 months of age. Administration of a mixture of Bacteroides shaped the development of gut microbiota in nursed piglets, which resulted in improved parameters at the end of the pre-fattening period. Full article
(This article belongs to the Special Issue Advances in Diet–Host–Gut Microbiome Interactions: Second Edition)
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