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Microorganisms
Special Issues
Microbiota in Human Health and Disease, 2nd Edition
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Microbiota in Human Health and Disease, 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 565

Special Issue Editors

Dr. Claire Morgan

E-Mail Website
Guest Editor
College of Medicine, Institute of Life Science, Swansea University, Swansea SA2 8PP, UK
Interests: cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Paul D. Facey

E-Mail Website
Guest Editor
Singleton Park Campus, Swansea University Medical School, Swansea SA2 8PP, UK
Interests: gut microbiome; microbiology; genome evolution
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this Special Issue, we invite researchers to submit manuscripts falling within the broad scope of "Microbiota in Human Health and Disease". We welcome original research papers, review articles, and case studies that focus on the interplay between microbial communities and their hosts. The primary goal of this collection is to showcase studies that not only deepen our understanding of the implications of changes in microbiota composition for disease states but also offer valuable insights into translational applications. Manuscripts exploring avenues for therapeutic and preventive interventions are of particular interest.

Dr. Claire Morgan
Dr. Paul D. Facey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiota
  • probiotics
  • prebiotics
  • synbiotics
  • biotherapeutics
  • probiogenomics
  • health and disease

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Related Special Issue

Published Papers (1 paper)

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Research

19 pages, 6589 KB  
Article
Cross-Host Adaptation of Campylobacter jejuni Is Shaped by Chromosomal Backgrounds and Mobile Gene Acquisition, with Human-Associated Traits Emerging Under Limited Mutational Diversification
by Yingdong Li, Zhifeng Ma, Jing Chi, Yinqiu Wang, Minjie Li, Qianru Wang, Lei Lei and Qingliang Chen
Microorganisms 2026, 14(4), 874; https://doi.org/10.3390/microorganisms14040874 - 13 Apr 2026
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Abstract
Campylobacter jejuni is a major zoonotic pathogen that circulates among birds, livestock, humans, and environmental reservoirs, yet the genomic mechanisms that enable persistence and transmission across divergent hosts remain incompletely understood. Here, we sequenced 61 C. jejuni isolates recovered from multiple host-associated sources [...] Read more.
Campylobacter jejuni is a major zoonotic pathogen that circulates among birds, livestock, humans, and environmental reservoirs, yet the genomic mechanisms that enable persistence and transmission across divergent hosts remain incompletely understood. Here, we sequenced 61 C. jejuni isolates recovered from multiple host-associated sources in Shenzhen, China, from 2016 to 2023, and analyzed them together with 312 dereplicated publicly available high-quality reference genomes. Phylogenomic analyses resolved three major clades, including one avian-restricted clade and two clades showing frequent cross-host occurrence. Human-associated isolates displayed lower coding density than mammal-associated isolates and significantly higher proteome-level carbon and nitrogen demands than avian-associated isolates. Comparative genomic analyses further revealed strong host-associated divergence in chromosome-encoded, plasmid-encoded, and horizontally acquired gene repertoires. In human-derived isolates, 11 dataset-specific human-unique KEGG genes and 48 human-unique virulence-associated genes were identified, and human-associated strains showed the strongest multidrug-resistance signal across both chromosome-encoded and mobile-gene compartments. Resistance-associated functions enriched in human-associated genomes included antibiotic inactivation, efflux-mediated resistance, target protection/replacement/alteration, reduced permeability, and nutrient-acquisition-associated resistance. By contrast, core host-interaction loci remained under strong purifying selection, indicating that major human-associated traits were linked more closely to mobile gene acquisition than to extensive mutation-driven diversification. Together, these findings support a proposed genome-partition framework of host adaptation in C. jejuni, in which relatively stable chromosomal backgrounds are complemented by rapid plasmid- and horizontal-transfer-mediated acquisition of high-impact accessory genes. Full article
(This article belongs to the Special Issue Microbiota in Human Health and Disease, 2nd Edition)
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