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Microorganisms
Special Issues
Applied Gut Molecular Microbiology Technology
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Applied Gut Molecular Microbiology Technology

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 916

Special Issue Editors

Dr. Donglei Sun

E-Mail Website
Guest Editor
School of Life Scences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
Interests: macrophage behavior; function and manupulation
Dr. Yi-Zhou Gao

E-Mail Website
Guest Editor
Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Beijing, China
Interests: gut microbiology; environmental microbiology; microbial biotechnology; microbial metabolism; microbe-host interactions

Special Issue Information

Dear Colleagues,

The application of gut microorganisms in medicine, industry, and other fields can produce great benefits. In addition, increasing the amount of basic research on microbiology will help its practical applications. The discovery of new methods in basic and applied microbiology can further promote its development.

Some food-grade probiotics maintain the balance of gut flora by producing acid and breaking down protein. Some pathogenic microorganisms also interact with their hosts with a variety of new and unknown mechanisms. Promoting the development of new technologies for the genetic engineering of basic microorganisms can increase technical support for the use and modification of probiotic strains for the treatment of immune diseases and the enhancement of human intestinal health. It also provides a technical basis for the study of microbial disease.

The objective is to expand both basic and applied microbiology research in order to unlock the vast potential of gut microorganisms for various medical, industrial, and scientific applications. Advancing genetic engineering capabilities for microbes is highlighted as a key area for enabling these advancements.

In this Special Issue of Microorganisms, we invite you to submit contributions (research articles, review articles, and short communications) concerning any aspects related to applied gut molecular microbiology technology.

Dr. Donglei Sun
Dr. Yi-Zhou Gao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microorganisms
  • applied microbiology
  • probiotics

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Published Papers (1 paper)

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Research

17 pages, 2099 KiB  
Article
Selection of Probiotics for Honey Bees: The In Vitro Inhibition of Paenibacillus larvae, Melissococcus plutonius, and Serratia marcescens Strain Sicaria by Host-Specific Lactobacilli and Bifidobacteria
by Buse Dengiz, Jiří Killer, Jaroslav Havlík, Pavel Dobeš and Pavel Hyršl
Microorganisms 2025, 13(5), 1159; https://doi.org/10.3390/microorganisms13051159 - 20 May 2025
Viewed by 575
Abstract
Host-specific Lactobacillus and Bifidobacterium species constitute the core microbiota of the honey bee digestive tract and are recognized for their probiotic properties. One of the properties of these bacteria is the inhibition of bacterial pathogens such as Paenibacillus larvae and Melissococcus plutonius, [...] Read more.
Host-specific Lactobacillus and Bifidobacterium species constitute the core microbiota of the honey bee digestive tract and are recognized for their probiotic properties. One of the properties of these bacteria is the inhibition of bacterial pathogens such as Paenibacillus larvae and Melissococcus plutonius, the causative agents of American and European foulbrood, respectively. Additionally, Serratia marcescens has emerged as a relevant opportunistic pathogen. Although several previously published studies have examined the inhibition of selected bacterial pathogens of bees by members of the bee physiological microbiota, none have simultaneously investigated the inhibition of multiple clinical isolates of P. larvae, M. plutonius, and S. marcescens using a wide range of bifidobacterial and lactobacilli strains isolated from various locations within a single country. Thus, this study evaluated the antimicrobial potential of Lactobacillus and Bifidobacterium strains against these pathogens, with a focus on strain-dependent inhibition. A total of 111 bacterial strains (62 Lactobacillus and 49 Bifidobacterium) were isolated from the digestive tracts of honey bees collected from eight sites across the Czech Republic. Using 16S rRNA gene sequencing, the isolates were classified and tested in vitro against four P. larvae isolates, one M. plutonius isolate, and the S. marcescens strain sicaria in modified BHI medium. Twenty-eight strains (~26%) exhibited strong inhibition (≥21 mm) against at least two P. larvae isolates, while 12 strains showed moderate inhibition (16–20 mm) against all four isolates. Inhibition of M. plutonius and S. marcescens was observed in three and twenty strains, respectively. The most effective strains belonged to Bifidobacterium asteroides, B. choladohabitans, B. polysaccharolyticum, Lactobacillus apis, L. helsingborgensis, L. kullabergensis, and L. melliventris. These results underscore the strain-dependent nature of antimicrobial activity and highlight the importance of selecting probiotic strains with broad-spectrum pathogen inhibition to support honey bee health. Full article
(This article belongs to the Special Issue Applied Gut Molecular Microbiology Technology)
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