Yeast Metabolic Engineering and Fermentation Technology

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 54

Special Issue Editor

Special Issue Information

Dear Colleagues,

Yeasts, as versatile microbial cell factories, have revolutionized the sustainable production of chemicals, pharmaceuticals, and food ingredients through metabolic engineering and advanced fermentation technologies. 

This Special Issue aims to focus on:

  • Discovery and engineering of synthetic catalytic/regulatory components‌ to enhance pathway efficiency and product diversity;
  • Reprogramming yeast metabolism‌ through systems biology approaches, including energy balancing, cofactor manipulation, and elimination of metabolic bottlenecks;
  • Development of novel yeast chassis (non-conventional yeasts) with improved stress tolerance, substrate utilization, and genetic stability;
  • Fermentation process innovations‌ for scalable production of target compounds, integrating multi-omics analysis, machine learning, and bioreactor engineering. 

By compiling advances in strain design, pathway regulation, and bioprocess optimization, this Special Issue seeks to accelerate the transition from laboratory breakthroughs to industrial applications in the circular bioeconomy. This issue will highlight interdisciplinary strategies to bridge synthetic biology, metabolic modeling, and industrial biotechnology. 

Dr. Yongjun Wei
Guest Editor

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Keywords

  • yeasts cell factories
  • metabolic engineering
  • synthetic biology
  • reprogramming
  • fermentation technology
  • multi-omics
  • machine learning
  • bioreactor engineering
  • engineering biotechnology
  • bioactive compounds

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Published Papers

This special issue is now open for submission.
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