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Diagnostics and Pathological Characterization of Aquatic Animal Pathogens

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Veterinary Microbiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2795

Special Issue Editors


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Guest Editor
Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Interests: aquatic animal pathology and disease diagnosis; prevention and control technology of aquatic animal diseases; aquatic animal health breeding; aquatic animal pathogenesis and immunology

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Co-Guest Editor
College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China
Interests: fish disease; fish immunology; aquatic vaccine
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Special Issue Information

Dear Colleagues,

The characterization of aquatic pathogens is a very crucial first step for disease control and prevention, but many emerging microbes with pathogenic potential are still not fully understood. In recent years, many modern analytical techniques for the diagnostics and characterization of pathogens have been remarkably advanced. Hence, we are in an era in which previously well-known pathogens are being re-identified and re-characterized, providing a better understanding of the disease as well as new perspectives.

This Special Issue aims to collect high-quality manuscripts (research articles, case reports, short communication, and reviews) relevant not only to the Diagnostics and Pathological Characterization of aquatic animal pathogens, but also new diagnostic methods and the understanding of host–pathogen interactions. Studies using modern technologies and bioinformatics are warmly welcome, but the scope is not strictly limited to these. We look forward to your important contributions.

Prof. Dr. Youlu Su
Dr. Yanwei Li
Guest Editor

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Keywords

  • aquatic animal pathogens
  • host–pathogen interactions
  • diagnostics of aquatic animal diseases

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Published Papers (1 paper)

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Research

16 pages, 2395 KiB  
Article
The Pleiotropic Phenotypes Caused by an hfq Null Mutation in Vibrio harveyi
by Yiqin Deng, Shujun Zang, Ziyang Lin, Liwen Xu, Changhong Cheng and Juan Feng
Microorganisms 2023, 11(11), 2741; https://doi.org/10.3390/microorganisms11112741 - 9 Nov 2023
Cited by 3 | Viewed by 1619
Abstract
Hfq is a global regulator and can be involved in multiple cellular processes by assisting small regulatory RNAs (sRNAs) to target mRNAs. To gain insight into the virulence regulation of Hfq in Vibrio harveyi, the hfq null mutant, ∆hfq, was [...] Read more.
Hfq is a global regulator and can be involved in multiple cellular processes by assisting small regulatory RNAs (sRNAs) to target mRNAs. To gain insight into the virulence regulation of Hfq in Vibrio harveyi, the hfq null mutant, ∆hfq, was constructed in V. harveyi strain 345. Compared with the wild-type strain, the mortality of pearl gentian sharply declined from 80% to 0% in ∆hfq when infected with a dose that was 7.5-fold the median lethal dose (LD50). Additionally, ∆hfq led to impairments of bacterial growth, motility, and biofilm formation and resistance to reactive oxygen species, chloramphenicol, and florfenicol. A transcriptome analysis indicated that the expression of 16.39% genes on V. harveyi 345 were significantly changed after the deletion of hfq. Without Hfq, the virulence-related pathways, including flagellar assembly and bacterial chemotaxis, were repressed. Moreover, eleven sRNAs, including sRNA0405, sRNA0078, sRNA0419, sRNA0145, and sRNA0097, which, respectively, are involved in chloramphenicol/florfenicol resistance, outer membrane protein synthesis, electron transport, amino acid metabolism, and biofilm formation, were significantly down-regulated. In general, Hfq contributes to the virulence of V. harveyi 345 probably via positively regulating bacterial motility and biofilm formation. It is involved in flagellar assembly and bacterial chemotaxis by binding sRNAs and regulating the target mRNAs. Full article
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