Advances in Aspergillus and Aspergillosis

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 775

Special Issue Editor


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Guest Editor
Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisbon, Portugal
Interests: fungal infections diagnosis; Aspergillus; fungi; infectious diseases; fungal epidemiology and public health; antifungal resistance; molecular biology
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Special Issue Information

Dear Colleagues,

Aspergillus diseases are a growing global concern; their incidence is increasing worldwide because of the rising numbers of immunosuppressed patients due to medical advancements and the increased prevalence of antifungal resistance.

In recent years, two previous Special Issues on Aspergillus and Health have encompassed different research areas, focusing on the unique and diverse genera Aspergillus.

Despite significant advancements in our understanding of Aspergillus species and Aspergillosis, critical knowledge gaps remain, especially in terms of understanding the environmental, clinical, and immunological factors driving these infections, as well as in developing effective strategies for prevention, diagnosis, and treatment.

Addressing these unmet issues requires interdisciplinary collaboration, integrating genomics, immunology, diagnosis, therapeutics, and environmental science. Enhanced focus on these challenges can pave the way for the development of innovative strategies to reduce the global health burden of Aspergillus.

Therefore, this Special Issue, entitled “Advances in Aspergillus and Aspergillosis”, aims to provide an update about the most recent research in this area tackling the referred-to challenges.

Dr. Raquel Sabino
Guest Editor

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Keywords

  • Aspergillus
  • Aspergillosis
  • integrating genomics
  • immunology
  • diagnosis
  • therapeutics
  • environmental science
  • antifungal resistance

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Published Papers (1 paper)

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Research

20 pages, 6905 KB  
Article
Comparative Enzymology and Biomass Hydrolysis Reveal Industrial Biorefining Potential of Aspergillus fumigatus Strain VP2T
by Vaniksha Pal, Punam Vishwakarma, Dipayan Samanta, Priya Saxena, Rohit Rai and Rajesh K. Sani
Microorganisms 2026, 14(3), 723; https://doi.org/10.3390/microorganisms14030723 - 23 Mar 2026
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Abstract
We report on the isolation and comprehensive genomic and biochemical characterization of Aspergillus fumigatus VP2T, a thermophilic filamentous fungus recovered from Himalayan Forest soil with exceptional lignocellulolytic capacity. Whole-genome sequencing revealed a 32.1 Mb genome encoding 12,675 predicted genes, including an extensive repertoire [...] Read more.
We report on the isolation and comprehensive genomic and biochemical characterization of Aspergillus fumigatus VP2T, a thermophilic filamentous fungus recovered from Himalayan Forest soil with exceptional lignocellulolytic capacity. Whole-genome sequencing revealed a 32.1 Mb genome encoding 12,675 predicted genes, including an extensive repertoire of >300 carbohydrate-active enzymes (CAZymes). Notably, the genome harbors multiple auxiliary activity enzymes, including AA9-family lytic polysaccharide monooxygenases and several cellobiose dehydrogenases (CDHs), supporting oxidative–hydrolytic synergism during biomass degradation. Submerged fermentation using a cellulose–wheat bran–rice straw substrate induced high enzyme titers, including 33 U/mL endoglucanase and 131 U/mL CDH, exceeding activities commonly reported for both native and engineered fungal strains. Although exoglucanase (0.02 U/mL) and xylanase (14.22 U/mL) activities were comparatively modest, the strain VP2T demonstrated superior hydrolysis of untreated rice straw, achieving a 1.89-fold increase in saccharification efficiency relative to the commercial enzyme cocktail Cellic® CTec2. Scanning electron microscopy confirmed extensive disruption of lignocellulosic architecture, consistent with enhanced enzyme accessibility and oxidative fiber loosening. Collectively, genomic evidence and functional assays identify A. fumigatus VP2T as a redox-optimized, moderately thermophilic biocatalyst suited for low-pH lignocellulose conversion. This study highlights the value of exploring thermophilic fungal biodiversity to discover native strains with inherent oxidative capacity, offering promising alternatives to pretreatment-intensive biorefinery processes and informing the rational development of tailored enzyme systems. Full article
(This article belongs to the Special Issue Advances in Aspergillus and Aspergillosis)
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