HIV Vaccine Research and Development: Challenges, Advancements, and Opportunities
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1395
Special Issue Editor
Interests: understanding the role of antibodies; support the development of efficacious vaccines against infectious diseases and establish global portfolio for vaccines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite significant advances in antiretroviral therapies, the global HIV/AIDS pandemic remains a major public health challenge, with 38 million people currently living with the virus and 1.7 million people newly infected each year. The extraordinary genetic diversity and rapid mutation rate of the virus are the primary obstacles for a protective HIV vaccine. Accordingly, researchers have focused on structure (including computational) -based vaccine design, which utilizes the detailed knowledge of HIV's molecular structure and the host immune response to develop innovative vaccine candidates.
This Special Issue will collect original research papers and review articles that highlight the challenges, progress, and potential solutions in the quest to create an HIV vaccine, with a focus on structure-based design. Potential topics include:
- Structure-guided immunogen design approaches, including the development of stabilized Env trimers or scaffolded epitope-focused immunogens and new understandings of the interactions between antigens and antibodies.
- New insights into the complex interplay between host immunity and HIVs, including the role of T-cell responses in vaccine-induced protection.
- Emerging technologies and computational approaches that facilitate the rational design of HIV vaccine candidates.
We hope that this collection of articles will inspire further research, collaboration, and innovation in the pursuit of an effective HIV vaccine, contributing to the global effort to end the HIV/AIDS pandemic.
Dr. Sanjay Phogat
Guest Editor
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Keywords
- structure-based vaccine design
- envelope glycoprotein (env)
- broadly neutralizing antibodies (bnabs)
- T-cell responses
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