Role of Dietary Nutrients in the Modulation of Gut Microbiota
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 3526
Special Issue Editors
Interests: gut microbiota; diet; immunomodulation; cardiometabolic health; gut-lung axis; dietary intervention studies
Special Issue Information
Dear Colleagues,
The interactions between diet, gut microbiota, and host health are intricate and multifaceted. Dietary patterns significantly influence the composition and function of the gut microbiota, which in turn affects host health through the production of various metabolites. These metabolites can have both beneficial and adverse effects on the host. Different components of the diet, such as protein, saturated and unsaturated fats, carbohydrates, and fibre influence the abundance of different types of bacteria in the gut, thereby regulating the gut microbiota's impact on health and disease. Emerging research highlights how gut microbiota also mediate immunomodulation and communicate with distal organs via the lymphatic and circulatory systems. This "common mucosal response" suggests that the gut microbiota and their metabolites influence not only local intestinal immunity but also immune responses in distant tissues, such as the lungs. Although the precise mechanisms remain unclear, systemic propagation of bacterial-derived components, metabolites, and migrating immune cells is implicated in this inter-organ communication. Furthermore, bidirectional interactions are evident; for instance, short-chain fatty acids from the gut can affect lung homeostasis and influence immune cell development in the bone marrow. By bridging the gap between diet and gut microbiota, this Special Issue seeks to elucidate the role of dietary nutrients in shaping gut microbiota and the broader implications for host health and disease. The exploration of mechanisms underlying local and systemic immune responses will be considered as an additional point of focus.
Dr. Inês Brandão
Dr. Joana Ferreira-Gomes
Guest Editors
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Keywords
- gut microbiota
- diet
- immunomodulation
- dietary intervention studies
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