Microorganisms

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Special Issue Information

Dear Colleagues,

The oral microbiome is a complex collection of microbial species, the balance of which contributes to the initiation and development of oral infectious disease processes, including dental caries, periodontitis and endodontic pathoses. The correct diagnosis permits to develop an adequate treatment plan. Blood and salivary biomarkers can be relevant in helping in this process. It can be applied in many medical subareas which can involve many types of systemic and oral diseases. Thus, this fact allows clinicians to make an informed decision on the diagnosis and treatment choice. Biomarkers exist in different forms belonging to five different fields: genomics transcriptomics proteomics interactomics and metabolomics. Changes in the concentration structure function or action of the various components can be associated with the onset progression or even regression of a disease. On this hand blood and salivary biomarkers serve as a valuable and attractive tool in the detection risk assessment diagnosis prognosis, monitoring of diseases and oral microoganisms.

Then studies involving biomarkers to diagnosis for oral diseases associated or not with systemic questions are very welcome to this special issue (Biomarkers in oral health and diseases: new advances and treatment strategies) in the journal Microorganisms.

Dr. Juliana Fernandes
Dr. Felipe Nör
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

biomarkers
blood
saliva
health
diseases
treatment
diagnosis

Published Papers (2 papers)

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Research

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16 pages, 3802 KiB

Open AccessArticle

Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP

by Yuki Yamamoto, Tomonori Kamiya, Megumu Yano, Vu Thuong Huyen, Masahiro Oishi, Miki Nishio, Akira Suzuki, Kishiko Sunami and Naoko Ohtani

Microorganisms 2023, 11(12), 2957; https://doi.org/10.3390/microorganisms11122957 - 10 Dec 2023

Viewed by 1252

Abstract

The incidence of oral cancer has recently been increasing worldwide, particularly among young individuals and women. The primary risk factors for head and neck cancers, including oral and pharyngeal cancers, are smoking, alcohol consumption, poor oral hygiene, and repeated exposure to mechanical stimuli. However, approximately one-third of the patients with oral and pharyngeal cancers are neither smokers nor drinkers, which points to the existence of other mechanisms. Recently, human microbes have been linked to various diseases, including cancer. Oral pathogens, especially periodontal pathobionts, are reported to play a role in the development of colon and other types of cancer. In this study, we employed a series of bioinformatics analyses to pinpoint Fusobacterium nucleatum as the predominant oral bacterial species in oral and pharyngeal cancer tissue samples. We successfully isolated Fn. polymorphum from the saliva of patients with oral cancer and demonstrated that Fn. polymorphum indeed promoted oral squamous cell carcinoma development by activating YAP in a mouse tongue cancer model. Our research offers scientific evidence for the role of the oral microbiome in oral cancer progression and provides insights that would help in devising preventative strategies against oral cancer, potentially by altering oral bacterial profiles. Full article

(This article belongs to the Special Issue Biomarkers in Oral Health and Diseases: New Advances and Treatment Strategies)

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Review

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17 pages, 930 KiB

Open AccessReview

Influence of the Probiotic L. reuteri on Periodontal Clinical Parameters after Nonsurgical Treatment: A Systematic Review

by Carlota Ochôa, Filipe Castro, José Frias Bulhosa, Conceição Manso, Juliana Campos Hasse Fernandes and Gustavo Vicentis Oliveira Fernandes

Microorganisms 2023, 11(6), 1449; https://doi.org/10.3390/microorganisms11061449 - 30 May 2023

Cited by 3 | Viewed by 1849

Abstract

The aim of this systematic review was to evaluate the actual efficacy of Lactobacillus reuteri (L. reuteri) on the periodontal clinical parameters when used concomitantly to the nonsurgical periodontal treatment. Searches were conducted through PubMed Central, Online Knowledge Library, Science Direct, Scielo, and Cochrane databases from 2012 to 2022. The focused question was “In patients with periodontitis, will the probiotic L. reuteri, when administrated as an adjunct to nonsurgical periodontal treatment, compared to the nonsurgical periodontal treatment alone, result in better clinical outcomes?” The following information was extracted from the articles: author and year of publication, type of study, follow-up, sample size and number of defects, and clinical characteristics and details. All included studies were qualitatively assessed using the Critical Appraisal tools according to the Joanna Briggs Institute. Twenty-four articles were full-text reading, but only 9 articles were included. The number of patients enrolled was 287, aged between 18 and 56 years. All periodontal parameters were evaluated. The “follow-up” varied (14, 40, 84, 90, 180, and 360 days). Most articles supported the clinical benefits of L. reuteri as an adjunct to SRP compared to SRP alone. A common finding at the beginning period was thatno statistically different results were observed between the test and control groups; otherwise, at the last period, a significant improvement was found in favor of the probiotic use (p = 0.001) for all the clinical parameters. The use of L. reuteri as an adjunct to nonsurgical periodontal treatment may result in significantly better clinical outcomes than nonsurgical periodontal treatment alone; but the conclusion must be carefully interpreted because of the heterogeneity found among the studies. Full article

(This article belongs to the Special Issue Biomarkers in Oral Health and Diseases: New Advances and Treatment Strategies)

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