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Microorganisms
Special Issues
Animal Viral Infectious Diseases, Second Edition
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Animal Viral Infectious Diseases, Second Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Veterinary Microbiology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 613

Editors

Dr. He Zhang

E-Mail Website
Guest Editor
Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
Interests: animals; pathogens; porcine sapelovirus; porcine reproductive and respiratory syndrome virus
Special Issues, Collections and Topics in MDPI journals
Prof. Changyou Xia

E-Mail Website
Guest Editor
Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
Interests: copy number variations; genetic diversity; adaptive evolution; swine genomics; animal model

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, titled “Animal Viral Infectious Diseases”. Animal viral infectious diseases are a significant threat to animal health. Unraveling how animal viral proteins exploit the host system to facilitate invasion and how hosts resist infection is crucial for understanding the pathogenesis of animal viruses. This knowledge can guide the formulation of strategies to combat infections, such as the development of new drugs or diagnostic tools. In animal research, the complex interactions between host cells and various livestock- and poultry-related infectious viral pathogens, including Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Classical Swine Fever Virus (CSFV), Porcine Epidemic Diarrhea Virus (PEDV), African Swine Fever Virus (ASFV), Avian Influenza Virus (AIV), Foot-and-Mouth Disease Virus (FMDV), and others, remain insufficiently explored. This Special Issue welcomes research on host–animal virus interactions, aiming to uncover the molecular mechanisms behind them and devise clinical solutions for major animal diseases. Meanwhile, the detection of animal infectious viruses is also key to preventing outbreaks, and novel detection methods enable faster and more accurate viral diagnosis. Therefore, we also encourage the submission of innovative detection kits and methods for clinical diagnosis and epidemiological investigations. By advancing research in this field, we hope to contribute to effective strategies for controlling animal viral infectious diseases.

Dr. He Zhang
Prof. Changyou Xia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal viral infectious diseases
  • host–animal virus interactions
  • pathogenesis
  • strategies to combat infections
  • new drug development
  • diagnostic tools
  • virus detection
  • epidemiological investigation

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Related Special Issue

Published Papers (1 paper)

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Research

17 pages, 4573 KB  
Article
Immunoevaluation of a Prokaryotic-Expressed Goose Circovirus Capsid Subunit Vaccine
by Wenchang Xue, Chao Wang, Zhanxin Yao, Jialong Chen, Jipei Zhang and Jidang Chen
Microorganisms 2026, 14(6), 1227; https://doi.org/10.3390/microorganisms14061227 - 29 May 2026
Viewed by 256
Abstract
To address the lack of a commercially available vaccine for goose circovirus (GoCV), we developed and evaluated a prokaryotically expressed subunit vaccine targeting the viral capsid (Cap) protein. A truncated Cap protein (GoCV-ΔCap) was expressed in Escherichia coli (E. coli) and [...] Read more.
To address the lack of a commercially available vaccine for goose circovirus (GoCV), we developed and evaluated a prokaryotically expressed subunit vaccine targeting the viral capsid (Cap) protein. A truncated Cap protein (GoCV-ΔCap) was expressed in Escherichia coli (E. coli) and formulated with aluminum hydroxide as a subunit vaccine (GoCVsubvac). Goslings were primed intramuscularly (i.m.) with high (75 µg) or low (15 µg) doses GoCVsubvac, followed by a boost 14 days later. At 14 days post-boost, goslings were challenged with GoCV and were administered a bivalent inactivated vaccine against Newcastle disease virus (NDV) and H9-subtype Avian influenza virus (AIV). Using our established gosling pathogenicity model, vaccine efficacy was evaluated via body weight, lesions, viral load, antibody titers, cytokine responses, and interference with NDV/AIV immunity. Results demonstrated that the GoCV-ΔCap vaccine, especially the high-dose formulation, provided effective immunoprotection. It elicited robust humoral and cellular immune responses, reduced lymphoid pathology, and decreased the viral detection rate in lymphoid tissues from 100% (5/5) in infected controls to 40% (2/5). Importantly, it alleviated GoCV-induced immunosuppression and preserved the immunogenicity of co-administered vaccines. This novel subunit vaccine is a promising candidate for controlling GoCV disease (GoCVD). Full article
(This article belongs to the Special Issue Animal Viral Infectious Diseases, Second Edition)
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