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Special Issue "Metabolism and Systems Biology Volume 2"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (30 June 2018).
Interests: systems biology; computational biology; biophysics
Interests: systems biology; metabolic engineering; human metabolism; metabolic modeling
Interests: Modelling of biological systems, Robustness analysis of biological networks, Modelling and analysis of heterogeneous cell populations, Dynamic optimization of metabolic networks
Special Issues and Collections in MDPI journals
The computational systems biology of cellular metabolism has grown into a rich field. Models are based on genome-scale stoichiometric descriptions of metabolic networks, but recent efforts are moving away from only modeling the metabolic network. Metabolism and expression (ME) models take, for instance, the synthesis reactions of all individual macromolecular components of the cell into account, such as of each mRNA and protein, leading to enormous models with much greater predictive accuracy. Other models consider reduced descriptions of metabolism and cellular growth to understand how particular constraints, such as limited biosynthetic machinery and protein-accessible volumes, influence cellular growth and how cells would be predicted to change their protein expression across conditions if they are maximizing their growth rate. Novel methods for optimal metabolic regulation are also being pioneered; in order to figure out how protein expression can be optimized in time, when particular cellular objective are optimized, such as total biomass formation within some time window or period of particular environmental conditions, such as circadian rhythm.
To help the biologists evaluate the specific characteristics of these modeling approaches, we think that it is helpful for the field to have a Special Issue of Metabolites dedicated to novel computational and theoretical methods in the systems biology of metabolism.
Topics that we deem relevant for this review collections are:
- Principles and illustrations of ME models;
- Physicochemical constraints and optimization of whole cell models;
- Optimality and metabolic regulation;
- Novel theoretical results related to metabolic regulation.
Prof. Dr. Frank J. Bruggeman
Prof. Dr. Steffen Waldherr
Prof. Dr. Radhakrishnan Mahadevan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.