Metabolism in Organ Development

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 3044

Special Issue Editor


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Guest Editor
Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
Interests: metabolic changes in normal and altered lung development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We have started to recognize more and more that proper metabolism is necessary not only for the homeostasis of different tissues, but that it can also induce gene expression and cell signaling. Many studies have now shown that metabolism is closely connected with many other intra and intercellular networks that regulate cellular fate and tissue function. Various problems in organ development involve a pathologically distorted metabolism. Proper organ development requires exquisite metabolic control, and it has been shown that a perturbed metabolism can result in developmental diseases. A lot of undetermined processes remain unknown in our understanding of the role of metabolic processes in developing organs and tissues. Given the amount and interconnection of metabolic networks, new systematic studies are needed.

Therefore, in this Special Issue “Metabolism in Organ Development”, we would like to bring together scientists exploring how metabolism can impact developmental processes in a wide range of model systems affect intra and inter-cellular signaling on the tissue and organ levels.

Dr. Evgenia Dobrinskikh
Guest Editor

Manuscript Submission Information

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Keywords

  • metabolism
  • organ development
  • metabolic signalin
  • metabolomics
  • gene expression
  • spatial metabolomics
  • imaging
  • metabolites
  • metabolic programming
  • tissue plasticity

Published Papers (1 paper)

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Research

17 pages, 4817 KiB  
Article
Metabolic Regulation of Hepatitis B Virus Infection in HBV-Transgenic Mice
by Wenning Lan, Yang Wang, Zixiong Zhou, Xia Sun, Yun Zhang and Fangrong Zhang
Metabolites 2022, 12(4), 287; https://doi.org/10.3390/metabo12040287 - 25 Mar 2022
Cited by 5 | Viewed by 2624
Abstract
Hepatitis B virus (HBV) infection is a worldwide health burden. Metabolomics analysis has revealed HBV-induced metabolism dysregulation in liver tissues and hepatocytes. However, as an infectious disease, the tissue-specific landscape of metabolic profiles of HBV infection remains unclear. To fill this gap, we [...] Read more.
Hepatitis B virus (HBV) infection is a worldwide health burden. Metabolomics analysis has revealed HBV-induced metabolism dysregulation in liver tissues and hepatocytes. However, as an infectious disease, the tissue-specific landscape of metabolic profiles of HBV infection remains unclear. To fill this gap, we applied untargeted nuclear magnetic resonance (NMR) metabolomic analysis of the heart, liver, spleen, lung, kidney, pancreas, and intestine (duodenum, jejunum, ileum) in HBV-transgenic mice and their wild-type littermates. Strikingly, we found systemic metabolic alterations induced by HBV in liver and extrahepatic organs. Significant changes in metabolites have been observed in most tissues of HBV-transgenic mice, except for ileum. The metabolic changes may provide novel therapeutic targets for the treatment of HBV infection. Moreover, tissue-specific metabolic profiles could speed up the study of HBV induced systemic metabolic reprogramming, which could help follow the progression of HBV infection and explain the underlying pathogenesis. Full article
(This article belongs to the Special Issue Metabolism in Organ Development)
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