Recent Advances in Radiation Research

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1521

Special Issue Editor


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Guest Editor
Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Wybrzeze Armii Krajowej 15, 44-102 Gliwice, Poland
Interests: ionizing radiation; radiotherapy; metabolomics; lipidomics; multi-omics

Special Issue Information

Dear Colleagues,

Ionizing radiation has become extensively used in health care as a therapeutic agent, but also as a diagnostic tool. Additionally, diverse exposure schemes such as space radiation or occupational exposure increase the importance of radiation protection issues. As a result, it is crucial to improve and update the understanding of the principles underlying the induction of radiation effects in biological targets and to apply the accumulated knowledge to optimize the medical use of radiation and protective procedures. The primary target of radiation is widely acknowledged to be DNA. However, the characteristics of the critical DNA damage type that leads to cell death or cell conversion to malignancy are still unclear. Following radiation exposure, a variety of biological mechanisms are activated. Radiation-induced damage causes alterations in intercellular communication (for example, radiation-induced bystander effect (RIBE)), inflammation, and immune responses, as well as tissue repair processes and the hypertrophy of remaining cells to compensate for apoptosis.

This Special Issue is primarily focused on metabolomic and lipidomic responses to ionizing radiation. However, it is also open to other omics research (preferably multi-omics) that can provide a comprehensive view at the cellular, tissue, or systemic levels (both experimentally and theoretically). Acquisition of more detailed knowledge of the experts in this research field will certainly lead to beneficial implications for radiotherapy and radiation protection.

Dr. Karol Jelonek
Guest Editor

Manuscript Submission Information

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Keywords

  • ionizing radiation
  • radiotherapy
  • space radiation
  • radiation protection
  • metabolomics
  • lipidomics
  • multi-omics

Published Papers (1 paper)

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19 pages, 6198 KiB  
Systematic Review
The Metabolic Footprint of Systemic Effects in the Blood Caused by Radiotherapy and Inflammatory Conditions: A Systematic Review
by Karol Jelonek, Katarzyna Mrowiec, Dorota Gabryś and Piotr Widłak
Metabolites 2023, 13(9), 1000; https://doi.org/10.3390/metabo13091000 - 09 Sep 2023
Cited by 1 | Viewed by 1021
Abstract
Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory reactions. We aimed to compare changes in metabolic patterns induced at the systemic level by radiation and inflammation itself. Patients treated with RT due to head and neck cancer and patients with [...] Read more.
Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory reactions. We aimed to compare changes in metabolic patterns induced at the systemic level by radiation and inflammation itself. Patients treated with RT due to head and neck cancer and patients with inflammation-related diseases located in the corresponding anatomical regions were selected. PubMed and Web of Science databases were searched from 1 January 2000 to 10 August 2023. Twenty-five relevant studies where serum/plasma metabolic profiles were analyzed using different metabolomics approaches were identified. The studies showed different metabolic patterns of acute and chronic inflammatory diseases, yet changes in metabolites linked to the urea cycle and metabolism of arginine and proline were common features of both conditions. Although the reviewed reports showed only a few specific metabolites common for early RT response and inflammatory diseases, partly due to differences in metabolomics approaches, several common metabolic pathways linked to metabolites affected by radiation and inflammation were revealed. They included pathways involved in energy metabolism (e.g., metabolism of ketone bodies, mitochondrial electron transport chain, Warburg effect, citric acid cycle, urea cycle) and metabolism of certain amino acids (Arg, Pro, Gly, Ser, Met, Ala, Glu) and lipids (glycerolipids, branched-chain fatty acids). However, metabolites common for RT and inflammation-related diseases could show opposite patterns of changes. This could be exemplified by the lysophosphatidylcholine to phosphatidylcholine ratio (LPC/PC) that increased during chronic inflammation and decreased during the early phase of response to RT. One should be aware of dynamic metabolic changes during different phases of response to radiation, which involve increased levels of LPC in later phases. Hence, metabolomics studies that would address molecular features of both types of biological responses using comparable analytical and clinical approaches are needed to unravel the complexities of these phenomena, ultimately contributing to a deeper understanding of their impact on biological systems. Full article
(This article belongs to the Special Issue Recent Advances in Radiation Research)
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