Special Issue "Metabolic Signature of Non-alcoholic Fatty Liver Disease in Children"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".

Deadline for manuscript submissions: 15 May 2022.

Special Issue Editor

Dr. Jin Soo Moon
E-Mail Website
Guest Editor
Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea
Interests: child; Korea; pediatrics; mutation; metabolomics; obesity; pediatric obesity; pediatric NAFLD; pediatric Crohn’s disease

Special Issue Information

Dear Colleagues,

The global epidemic of pediatric obesity is a major burden of disease in our generation and will also impact the future. To intervene this problem, it is very important to assess the severity of the obesity and its associated metabolic syndrome, and to detect the factors associated with risk stratification. Among the metabolic comorbidities, pediatric non-alcoholic fatty liver disease (NAFLD) is regarded as a core element to identify high-risk patients. However, metabolic signatures in pediatric NAFLD have not been well-known up to now, compared to the other associated health problems. ‘Multi-omics’ signatures including metabolomics, lipidomics, proteomics, genomics, and metagenomics could provide us with informative guidance for the risk stratification in patients with NAFLD. Samples from the various body components and fluids such as blood, urine, stool, saliva, and respiratory gas could provide us with a variety of access points to gain useful information. We should expand our knowledge about the metabolic signatures about NAFLD to meet the urgent needs.

This Special Issue of Metabolites, "Metabolic Signature of Non-Alcoholic Fatty Liver Disease in Children", will be dedicated not only to in-depth applications of metabolomics techniques to the biotechnology field, but also to cutting-edge technology development for detailed ‘metabolotyping’, from both fundamental and applied points of view. The topics that will be covered by this Special Issue include, but are not limited to: the functional genomics that identify novel metabolites and gene functions, any metabolic data interpretation with diet and anthropometric information, and any metabolic signatures associated with NAFLD in pediatric longitudinal data. Manuscripts dealing with other challenging issues are also highly desired. Any human data relevant to this Issue covering ages from the fetus to young adults are welcomed. Animal data related to NAFLD in the context of growth and maturation are also welcome.

Dr. Jin Soo Moon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • obesity
  • diet
  • fatty liver
  • non-alcoholic fatty liver disease
  • child
  • adolescent
  • metabolomics
  • lipidomics
  • proteomics
  • genomics

Published Papers (1 paper)

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Metabolomic Signatures for the Effects of Weight Loss Interventions on Severe Obesity in Children and Adolescents
Metabolites 2022, 12(1), 27; https://doi.org/10.3390/metabo12010027 - 30 Dec 2021
Viewed by 211
Childhood obesity has increased worldwide, and many clinical and public interventions have attempted to reduce morbidity. We aimed to determine the metabolomic signatures associated with weight control interventions in children with obesity. Forty children from the “Intervention for Children and Adolescent Obesity via [...] Read more.
Childhood obesity has increased worldwide, and many clinical and public interventions have attempted to reduce morbidity. We aimed to determine the metabolomic signatures associated with weight control interventions in children with obesity. Forty children from the “Intervention for Children and Adolescent Obesity via Activity and Nutrition (ICAAN)” cohort were selected according to intervention responses. Based on changes in body mass index z-scores, 20 were responders and the remaining non-responders. Their serum metabolites were quantitatively analyzed using capillary electrophoresis time-of-flight mass spectrometry at baseline and after 6 and 18 months of intervention. After 18 months of intervention, the metabolite cluster changes in the responders and non-responders showed a difference on the heatmap, but significant metabolites were not clear. However, regardless of the responses, 13 and 49 metabolites were significant in the group of children with obesity intervention at 6 months and 18 months post-intervention compared to baseline. In addition, the top five metabolic pathways (D-glutamine and D-glutamate metabolism; arginine biosynthesis; alanine, aspartate, and glutamate metabolism; TCA cycle (tricarboxylic acid cycle); valine, leucine, and isoleucine biosynthesis) including several amino acids in the metabolites of obese children after 18 months were significantly changed. Our study showed significantly different metabolomic profiles based on time post obesity-related intervention. Through this study, we can better understand and predict childhood obesity through metabolite analysis and monitoring. Full article
(This article belongs to the Special Issue Metabolic Signature of Non-alcoholic Fatty Liver Disease in Children)
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