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Metabolites
Special Issues
Circadian Disruption and Metabolic Disorder
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Circadian Disruption and Metabolic Disorder

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 June 2021) | Viewed by 3806

Special Issue Editors

Prof. Ioannis (Yannis) P. Androulakis

E-Mail Website
Guest Editor
Biochemical Engineering Department, Rutgers the State University of New Jersey, Piscataway, NJ 08854, USA
Interests: systems biology of circadian; immune and metabolic interactions; quantitative systems pharmacology
Prof. Dr. Vinod Rustgi

E-Mail Website
Guest Editor
Rutgers – Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Interests: gastroenterology; liver disease

Special Issue Information

Dear Colleagues,

Lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag seriously impact metabolic homeostasis. Metabolic dysfunction due to the chronic misalignment of an organism’s endogenous rhythms is detrimental to health, and is a major contributor to metabolic disorders, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes, and cancer. This Special Issue of Metabolites, “Circadian Rhythms and Metabolic Disorders”, is dedicated to providing a comprehensive view of the relations between circadian disruption, metabolic disorders, and health.

  • Topics of interest include:
    Circadian disruption and metabolic syndrome, and specifically relations to diabetes, liver disease, obesity, and cardiovascular disease;
  • Circadian -omics and metabolic disorders;
  • The gut microbiome, circadian rhythms, and metabolic disorders;
  • The role of race, sex, and age in circadian disruption and metabolic disorders;
  • The role of lifestyle and behaviors in exacerbating the metabolic implications of circadian disruption;
  • The role of time-restricted feeding as a metabolic entrainment in the context of circadian disruption;
  • The circadian clock as an intervention target in metabolic disorders;
  • Systems biology approaches to understanding the role of circadian rhythms in metabolism and metabolic disorders.

Manuscripts dealing with other relevant challenging issues are also highly desired.

Prof. Ioannis (Yannis) P. Androulakis
Prof. Vinod Rustgi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Circadian rhythms
  • Metabolic disorders
  • Obesity
  • Diabetes
  • Cardiovascular disease
  • Omics
  • Microbiome
  • Personalized medicine

Published Papers (1 paper)

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Research

19 pages, 4628 KiB  
Article
Modeling the Influence of Chronic Sleep Restriction on Cortisol Circadian Rhythms, with Implications for Metabolic Disorders
by Rohit Rao, Pramod Somvanshi, Elizabeth B. Klerman, Charles Marmar and Francis J. Doyle III
Metabolites 2021, 11(8), 483; https://doi.org/10.3390/metabo11080483 - 27 Jul 2021
Cited by 9 | Viewed by 3351
Abstract
Chronic sleep deficiency is prevalent in modern society and is associated with increased risk of metabolic and other diseases. While the mechanisms by which chronic sleep deficiency induces pathophysiological changes are yet to be elucidated, the hypothalamic–pituitary–adrenal (HPA) axis may be an important [...] Read more.
Chronic sleep deficiency is prevalent in modern society and is associated with increased risk of metabolic and other diseases. While the mechanisms by which chronic sleep deficiency induces pathophysiological changes are yet to be elucidated, the hypothalamic–pituitary–adrenal (HPA) axis may be an important mediator of these effects. Cortisol, the primary hormone of the HPA axis, exhibits robust circadian rhythmicity and is moderately influenced by sleep and wake states and other physiology. Several studies have explored the effects of acute or chronic sleep deficiency (i.e., usually from self-selected chronic sleep restriction, CSR) on the HPA axis. Quantifying long-term changes in the circadian rhythm of cortisol under CSR in controlled conditions is inadequately studied due to practical limitations. We use a semi-mechanistic mathematical model of the HPA axis and the sleep/wake cycle to explore the influence of CSR on cortisol circadian rhythmicity. In qualitative agreement with experimental findings, model simulations predict that CSR results in physiologically relevant disruptions in the phase and amplitude of the cortisol rhythm. The mathematical model presented in this work provides a mechanistic framework to further explore how CSR might lead to HPA axis disruption and subsequent development of chronic metabolic complications. Full article
(This article belongs to the Special Issue Circadian Disruption and Metabolic Disorder)
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