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Metabolites
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Profiling of Bone Marrow Adipose Tissue Cells and Metabolism
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Profiling of Bone Marrow Adipose Tissue Cells and Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (5 December 2024) | Viewed by 1256

Special Issue Editors

Dr. Drenka Trivanovic

E-Mail Website
Guest Editor
Group for Hematology and Stem Cells, Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia
Interests: stem cells; bone marrow adipose tissue; cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Nina Krako Jakovljević

E-Mail Website
Guest Editor
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia
Interests: mitochondrial physiology; bioenergetics; neurobiology; energy metabolism

Special Issue Information

Dear Colleagues,

Bone marrow adipose tissue (BMAT) represents a metabolically unique adipose depot within the skeletal system. BMAT interacts with other bone marrow niches, affecting hematopoietic and skeletal system health. The adipogenic differentiation of subsets of adipocytic progenitors within bone marrow is coupled with a set of metabolic and bioenergetic changes in bone marrow niche cells. Being responsive to nutritional, environmental, and hormonal stimuli, bone marrow adipocytes have important endocrine and metabolic roles that can overcome the bone marrow niche. A postnatal increase in human BMAT occurs during aging, and its overexpansion can be associated with the progression of obesity, diabetes, skeletal diseases, and malignancies. However, we still do not understand the molecular background of BMAT maintenance and expansion, nor the metabolic reprogramming that leads to the establishment of an undesirable BMAT phenotype.

Revealing the metabolic reprogramming involved in the cellular identity of BMAT can contribute to novel strategies for the improvement of human health during aging and with pathologies. For this, new approaches defining the metabolic profile of BMAT at the cellular and molecular levels are required. This Special Issue will include research articles and reviews that aim to elucidate BMAT cell metabolism in aging and diseases.

Dr. Drenka Trivanovic
Dr. Nina Krako Jakovljević
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone marrow adipose tissue
  • adipocytes
  • mitochondria
  • lipids
  • nutrition
  • cancer
  • hematopoiesis
  • skeletal system
  • aging

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Published Papers (1 paper)

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Research

13 pages, 7237 KiB  
Article
Skeletal Site-Specific Lipid Profile and Hematopoietic Progenitors of Bone Marrow Adipose Tissue in Patients Undergoing Primary Hip Arthroplasty
by Drenka Trivanović, Marko Vujačić, Aleksandra Arsić, Tamara Kukolj, Milica Rajković, Nikola Bogosavljević, Zoran Baščarević, Mirjana Maljković Ružičić, Jovana Kovačević and Aleksandra Jauković
Metabolites 2025, 15(1), 16; https://doi.org/10.3390/metabo15010016 - 4 Jan 2025
Viewed by 837
Abstract
Background/Objectives: Bone marrow adipose tissue (BMAT) has been described as an important biomechanic and lipotoxic factor with negative impacts on skeletal and hematopoietic system regeneration. BMAT undergoes metabolic and cellular adaptations with age and disease, being a source of potential biomarkers. However, there [...] Read more.
Background/Objectives: Bone marrow adipose tissue (BMAT) has been described as an important biomechanic and lipotoxic factor with negative impacts on skeletal and hematopoietic system regeneration. BMAT undergoes metabolic and cellular adaptations with age and disease, being a source of potential biomarkers. However, there is no evidence on the lipid profile and cellularity at different skeletal locations in osteoarthritis patients undergoing primary hip arthroplasty. Methods: Acetabular and femoral bone marrow (BM) and gluteofemoral subcutaneous adipose tissue (gfSAT) were obtained from matched patients undergoing hip replacement surgery. BM, BMAT, and gfSAT were explored at the levels of total lipids, fatty acids, and cells by using thin-layerand gas chromatography, ex vivo cellular assays, and flow cytometry. Results: BMAT content was significantly higher in femoral than in acetabular BM. Total lipid analyses revealed significantly lower triglyceride content in femoral than in acetabular BMAT and gfSAT. Frequencies of saturated palmitic, myristic, and stearic acids were higher in femoral than in acetabular BMAT and gfSAT. The content of CD45+CD34+ cells within femoral BMAT was higher than in acetabular BMAT or gfSAT. This was associated with a higher incidence of total clonogenic hematopoietic progenitors and late erythroid colonies CFU-E in femoral BMAT when compared to acetabular BMAT, similar to their BM counterparts. Conclusions: Collectively, our results indicate that the lipid profiles of hip bone and femoral BMAT impose significantly different microenvironments and distributions of cells with hematopoietic potential. These findings might bring forth new inputs for defining BMAT biology and setting novel directions in OA disease investigations. Full article
(This article belongs to the Special Issue Profiling of Bone Marrow Adipose Tissue Cells and Metabolism)
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