Mitochondrial Metabolism in Health and Disease: A Clinical Perspective
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1169
Special Issue Editors
Interests: biochemistry; cell biology; molecular biology; metabolism; cancer
Special Issues, Collections and Topics in MDPI journals
2. iCBR - Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine (Health Sciences Pole), University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
3. CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-507 Coimbra, Portugal
4. Institute for Interdisciplinary Research (IIIUC), Casa Costa Alemão - Pólo II, University of Coimbra, Rua D. Francisco de Lemos, 3030-789 Coimbra, Portugal
Interests: cell biology; health sciences; neurochemistry; (neuro)endocrinology; (neuro)pharmacology/(neuro)toxicology; (patho)physiology
Special Issues, Collections and Topics in MDPI journals
Interests: Metabolism, cardiac mitochondria, Cardiovascular diseases, Developmental origins of health and disease (DOHaD), maternal and fetal health
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since their likely endosymbiotic origin, mitochondria have been a major feature of eukaryotic cells. Their major mitochondrial functions include ATP production, mediated by the mitochondrial oxidative phosphorylation system, the triggering of apoptosis, encompassing the mitochondrial outer membrane permeabilization, and the regulation of calcium homeostasis through interactions with the endoplasmic reticulum. Mitochondria are also implicated in the production and detoxification of reactive oxygen species (ROS), being particularly susceptible to oxidative stress and major players in redox homeostasis. Mitochondria have their own genome and are highly dynamic organelles, undergoing fusion and fission, being involved in the regulation of innumerous cellular activities, including cell-cycle regulation, cell differentiation, cell proliferation, mitophagy, and autophagy. Due to the critical role of mitochondria in cell homeostasis and metabolism, mitochondrial dysfunctions can have a severe impact on the host, being involved in disorders including cancer and metabolic, cardiac, and neurodegenerative diseases.
In this Special Issue, we aim to collect a sample of the latest research in mitochondrial metabolism. Altogether, the articles published in this collection will reinforce the significance of this organelle in the functioning of the cell and in human diseases. We welcome original research and review manuscripts on any aspects of mitochondrial metabolism, including mitochondrial dynamics, mitochondrial genetics, bioenergetics, the intrinsic pathway of apoptosis, the regulation of calcium levels, and oxidative stress. Studies on mitochondrial dysfunction in human disorders, including cancer and metabolic, cardiac, and neurodegenerative diseases, are also welcome. As the mitochondrion is a common link among these fields, participating researchers may uncover broader implications to their findings.
Dr. Joao Pessoa
Dr. Ana I. Duarte
Dr. Susana P. Pereira
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrion
- bioenergetics
- oxidative stress
- calcium homeostasis
- apoptosis
- cancer
- metabolic diseases
- cardiovascular diseases
- neurodegenerative diseases
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