Tumoral Microenvironment and Metabolic Reprogramming in Cancer
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 15 July 2026 | Viewed by 46
Special Issue Editor
2.Center for Advanced Studies and Technology (CAST), ‘G. d’Annunzio’ University of Chieti-Pescara, 66100 Chieti, Italy
Interests: inflammation; cancer; immune system; tumoral microenvironment; metabolic reprogramming; autoimmune disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer metabolism has emerged as a central topic of scientific research over the past twenty years. Metabolic reprogramming is a hallmark of cancer, essential to sustain malignant transformation, tumoral growth, and metastatic process. Several factors regulate tumor metabolism, including genetic alteration and microenvironment. The tumor microenvironment can not only modulate the metabolic profiles of cancer cells but can also undergo a metabolic shift itself. Altered glucose, amino acid, and lipid metabolism can occur in tumor-associated macrophages and cancer-associated fibroblasts, as well as in cancer cells. Elucidating the molecular determinants through which metabolic reprogramming sustains neoplastic cell proliferation necessitates a highly resolved, system-level framework for characterizing the spatiotemporal evolution of metabolic phenotypes during tumorigenesis. Achieving this objective requires the comprehensive metabolic profiling of both the tumor cell compartment and the associated tumor microenvironment. The delineation of discrete metabolic alterations that give rise to therapeutically actionable vulnerabilities similarly relies on the deployment of such an advanced mechanistic paradigm. This Special Issue will take stock of the complex networks between the tumoral microenvironment, metabolic reprogramming, and cancer progression. This Special Issue will consider original research, short communications, and reviews based on, but not limited to, studying the intricate interplay between metabolic shift and the tumor microenvironment.
Dr. Beatrice Dufrusine
Guest Editor
Manuscript Submission Information
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Keywords
- tumoral microenvironment
- inflammation
- cancer
- immune system
- stromal cells
- metabolic reprogramming
- warburg effect
- reverse warburg effect
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