Nutritional Interventions and Lipid Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2140

Special Issue Editors


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Guest Editor
ABC-Bioresearch s.r.l., Via IV Novembre 24, 37126 Verona, Italy
Interests: chronic disease; bioactive compounds; lipoxidation; inflammation; lipid metabolism

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Montesano 49, 80149 Naples, Italy
Interests: mechanism of action of antioxidants; interaction food and genes; cell biology; nutraceuticals; food supplements; metabolic syndrome
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Special Issue Information

Dear Colleagues,

Lipid metabolism is a fundamental biological process that is essential for energy storage, cellular function, and the production of signalling molecules. Dysregulation of lipid metabolism contributes to various chronic diseases, including cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease, and certain cancers. While genetic factors play a significant role, nutritional determinants have emerged as critical, modifiable contributors to lipid homeostasis.

This special issue “Nutritional Interventions and Lipid Metabolism" of Metabolites invites original research articles, comprehensive reviews, and concise communications that delve into the complex interplay between nutritional interventions and lipid metabolism. We aim to showcase cutting-edge research elucidating how dietary components, food patterns, and nutritional strategies influence lipids' synthesis, transport, breakdown, and storage, along with their downstream metabolic consequences.

We particularly welcome submissions addressing the following topics:

- Bioactive compounds in natural products as well as lipid profiles of dietary fat types, functional foods, and supplements;

- Lipid metabolism adaptation to macronutrients, micronutrients, probiotics, and prebiotics;

- Role of lipids in physiology and pathology, including their involvement in inflammatory and oxidative pathways, as well as endocrine regulation;

- Synergy between lipids and physical activity, along with strategies designed to enhance lipid utilization during physical activity;

- Role of lipids in weight management, nutrigenomics, and personalized nutrition, including nutritional interventions in specific populations like pediatric, adolescent, postmenopausal women, and the elderly.

We encourage submissions that utilize robust in vitro and in vivo experimental designs and clinical trials, aiming to provide novel insights into the intricate relationships between diet and lipid metabolism. Our goal is to deepen the understanding of the role lipids play in metabolic health and disease prevention and anticipate their use in potential therapeutic strategies.

Dr. Cecilia Bender
Prof. Dr. Mariano Stornaiuolo
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid metabolism
  • nutritional interventions
  • dietary fats
  • bioactive compounds
  • functional foods
  • chronic diseases
  • nutrigenomics
  • weight management
  • inflammation
  • personalized nutrition

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Published Papers (2 papers)

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Research

19 pages, 6598 KB  
Article
Polygoni Multiflori Radix Improves Dyslipidemia by Regulating Hepatocyte Lipid Metabolism Mediated via the AMPK/SREBP-2/PCSK9/LDLR Signaling Pathway
by Tongye Wang, Lijuan Zhang, Yue Wang, Jianguo Xing, Lei Xu, Xu Hu, Wenling Su and Ruifang Zheng
Metabolites 2026, 16(4), 230; https://doi.org/10.3390/metabo16040230 - 31 Mar 2026
Viewed by 676
Abstract
Objective: To clarify the molecular mechanism of Polygoni Multiflori Radix in improving dyslipidemia and provide a scientific basis for its clinical application. Methods: Network pharmacology, molecular docking and simulation were used to predict and verify active components and core targets of Polygoni Multiflori [...] Read more.
Objective: To clarify the molecular mechanism of Polygoni Multiflori Radix in improving dyslipidemia and provide a scientific basis for its clinical application. Methods: Network pharmacology, molecular docking and simulation were used to predict and verify active components and core targets of Polygoni Multiflori Radix. HFD-induced hyperlipidemic mice were grouped and administered for 28 days; serum indices, hepatic pathology and AMPK/SREBP-2/PCSK9/LDLR pathway expression were detected. Results: Twenty-two active components, 101 potential targets and the AMPK pathway (core) were identified. TSG, its main component, bound stably to AMPK/SREBP-2/PCSK9/LDLR. Polygoni Multiflori Radix dose-dependently improved HFD-induced abnormalities in mice (p < 0.05 or p < 0.01). Conclusions: Polygoni Multiflori Radix effectively improves HFD-induced dyslipidemia by regulating the AMPK/SREBP-2/PCSK9/LDLR pathway to ameliorate hepatocyte lipid metabolism and reduce oxidative stress/liver injury. Full article
(This article belongs to the Special Issue Nutritional Interventions and Lipid Metabolism)
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23 pages, 7029 KB  
Article
Antioxidant Clove Extract Inhibits Lipid Droplet Accumulation and Lipid Oxidation in Hepatocytes
by Satomi Monde, Dya Fita Dibwe, Shion Iwasaki and Shu-Ping Hui
Metabolites 2026, 16(1), 7; https://doi.org/10.3390/metabo16010007 - 22 Dec 2025
Viewed by 1068
Abstract
Background: Recent studies have shown that plant-based dietary extracts can prevent the formation of lipid droplets (LDs) and oxidized lipid droplets (oxLDs) in liver cells. These results indicate that these extracts might be useful in addressing metabolic dysfunction-associated fatty liver disease (MAFLD) and [...] Read more.
Background: Recent studies have shown that plant-based dietary extracts can prevent the formation of lipid droplets (LDs) and oxidized lipid droplets (oxLDs) in liver cells. These results indicate that these extracts might be useful in addressing metabolic dysfunction-associated fatty liver disease (MAFLD) and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH). In our ongoing study, we evaluated the potential of various food extracts to inhibit the accumulation and oxidation of LDs in liver cells to prevent metabolic MAFLD and MASH. Methods: The antioxidant activity index was determined using the DPPH assay, cell viability was assessed via cytotoxicity and lipotoxicity, and lipid droplet accumulation inhibition (LDAI) assays were performed. Metabolome analysis was performed using 1D-NMR [1H, 13C, DEPT 90, and 135] techniques. Results: Dietary clove (Syzygium aromaticum) extract exhibited antioxidant properties and inhibited linoleic acid-induced lipid droplet (LD) accumulation (LDA) and oxidized LDA (oxLDA) in HepG2 cells. Additionally, an analysis of the metabolome of dietary clove bioactive LDAI using 1D-NMR showed that clove extract (CE) mainly consists of hydroxybenzoic acids (HBAs) and hydroxycinnamic acids (HCAs), along with minor amounts of carbohydrates, coumarins, polyphenolic compounds, and small quantities of polyols, fatty acyls, small peptides, and amino acids. This suggests that CE could be a promising resource for developing functional foods and nutraceuticals and discovering drugs for treating MAFLD, MASH, and related conditions. Full article
(This article belongs to the Special Issue Nutritional Interventions and Lipid Metabolism)
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