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Metabolites
Special Issues
NMR-Metabolomics in Peptide and Antibody Drug Discovery
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NMR-Metabolomics in Peptide and Antibody Drug Discovery

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1221

Special Issue Editors

Dr. Michela Buonocore

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Guest Editor
Department of Chemical Sciences, University of Naples “Federico II”, Complesso Universitario di Monte Sant’Angelo, Via Cintia, 80126 Naples, Italy
Interests: peptides; solution NMR; molecular dynamics; nanobiotechnology; mesenchymal stem cells
Prof. Dr. Anna Maria D’Ursi

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Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
Interests: peptides; metabolomics; solution NMR; structural biology; biochemistry
Dr. Angelo Santoro

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Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
Interests: peptides; structural biology; NMR solution; gene expression; neurodegenerative diseases
Dr. Carmen Marino

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Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
Interests: metabolomics; data analysis; clinical biochemistry; machine Learning; solution NMR

Special Issue Information

Dear Colleagues,

Nuclear-magnetic-resonance (NMR)-based metabolomics represents a powerful tool in the field of peptide and antibody drug discovery. By exploiting the principles of NMR spectroscopy, it is possible to probe the metabolic profiles of biological samples, offering valuable insights into the efficacy and safety of peptide and antibody drugs. This approach allows the comprehensive analysis of metabolite concentrations and profiles, aiding in the identification of potential biomarkers indicative of drug response or toxicity. Moreover, NMR metabolomics facilitates the elucidation of mechanisms of action and the optimization of drug candidates, providing useful information on how drugs interact with biological systems. Through this methodology, researchers can streamline the drug discovery process, improving their efficiency and success rate when developing new peptide and antibody therapeutics. This Special Issue aims to focus on a new approach based on pharmacometabolomics, to elucidate the complex interplay between peptides and biological systems, driving innovation in the field of drug discovery.

Dr. Michela Buonocore
Prof. Dr. Anna Maria D’Ursi
Dr. Angelo Santoro
Dr. Carmen Marino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NMR metabolomics
  • peptides
  • antibodies
  • drug discovery
  • metabolomic profiles
  • biomarkers
  • mechanisms of action

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Published Papers (1 paper)

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Review

53 pages, 1912 KiB  
Review
Endoplasmic Reticulum Stress and Its Role in Metabolic Reprogramming of Cancer
by Salvatore Zarrella, Maria Rosaria Miranda, Verdiana Covelli, Ignazio Restivo, Sara Novi, Giacomo Pepe, Luisa Tesoriere, Manuela Rodriquez, Alessia Bertamino, Pietro Campiglia, Mario Felice Tecce and Vincenzo Vestuto
Metabolites 2025, 15(4), 221; https://doi.org/10.3390/metabo15040221 - 24 Mar 2025
Viewed by 872
Abstract
Background/Objectives: Endoplasmic reticulum (ER) stress occurs when ER homeostasis is disrupted, leading to the accumulation of misfolded or unfolded proteins. This condition activates the unfolded protein response (UPR), which aims to restore balance or trigger cell death if homeostasis cannot be achieved. In [...] Read more.
Background/Objectives: Endoplasmic reticulum (ER) stress occurs when ER homeostasis is disrupted, leading to the accumulation of misfolded or unfolded proteins. This condition activates the unfolded protein response (UPR), which aims to restore balance or trigger cell death if homeostasis cannot be achieved. In cancer, ER stress plays a key role due to the heightened metabolic demands of tumor cells. This review explores how metabolomics can provide insights into ER stress-related metabolic alterations and their implications for cancer therapy. Methods: A comprehensive literature review was conducted to analyze recent findings on ER stress, metabolomics, and cancer metabolism. Studies examining metabolic profiling of cancer cells under ER stress conditions were selected, with a focus on identifying potential biomarkers and therapeutic targets. Results: Metabolomic studies highlight significant shifts in lipid metabolism, protein synthesis, and oxidative stress management in response to ER stress. These metabolic alterations are crucial for tumor adaptation and survival. Additionally, targeting ER stress-related metabolic pathways has shown potential in preclinical models, suggesting new therapeutic strategies. Conclusions: Understanding the metabolic impact of ER stress in cancer provides valuable opportunities for drug development. Metabolomics-based approaches may help identify novel biomarkers and therapeutic targets, enhancing the effectiveness of antitumor therapies. Full article
(This article belongs to the Special Issue NMR-Metabolomics in Peptide and Antibody Drug Discovery)
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