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Metabolites
Special Issues
The Role of Phytonutrients in Metabolic Disorders
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The Role of Phytonutrients in Metabolic Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 4309

Special Issue Editors

Dr. Azhar Rasul

E-Mail Website
Guest Editor
Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Punjab 38000, Pakistan
Interests: chemical biology; natural products; cancer biology; tumor metabolism; signaling pathways; enzymology
Dr. Şevki Adem

E-Mail Website
Guest Editor
Department of Chemistry, Cankiri Karatekin University, Cankiri 18100, Turkey
Interests: biochemistry; phenolic compounds; biotechnology; enzyme activity; molecular docking; drug discovery

Special Issue Information

Dear Colleagues,

During the last decade, metabolic disorders posing one of the greatest threats to health. Metabolic disorders are defined as inborn errors of metabolism, encompassing deficiencies in enzymes involved in the metabolism of carbohydrates, amino acids derived from proteins, and fatty acids liberated from lipids. The metabolic disorders represent a cluster of metabolic abnormalities which includes diabetes, cancer, obesity, hypertension, hemochromatosis and phenylketonuria. Increasing knowledge of the molecular mechanisms underlying metabolic disorders has led to the development of a vast number of drugs. The use of chemically synthesized drugs has not significantly improved the overall survival rate. As a result, the role of dietary bioactive substances in features of metabolic disorder have been extensively investigated. Phytonutrients are promising options to improve treatment efficiency and decrease the adverse reactions. Due to their multiple properties, phytonutrients have demonstrated to provide positive effects in obesity, diabetes, cancer and hypertension.

Therefore, this special issue is based on the importance of phytonutrients in metabolic disorders. It will provide the platform to authors and encourage them that there is great need to conduct research on the key regulatory mechanisms and clinical potential of phytonutrients in metabolic pathways. We welcome authors to submit their research papers, mini reviews , review articles, and short communications to share the recent advances on phytonutrients which provides the insight into clinical uses to evaluates phytonutrients as a source of new drug candidate molecules for metabolic disorders.

Dr. Azhar Rasul
Dr. Şevki Adem
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic disorders
  • phytonutrients
  • diabetes
  • cancer
  • obesity
  • hypertension

Published Papers (2 papers)

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Research

16 pages, 4131 KiB  
Article
Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats
by Humaira Muzaffar, Iqra Qamar, Muhammad Bashir, Farhat Jabeen, Shahzad Irfan and Haseeb Anwar
Metabolites 2023, 13(4), 516; https://doi.org/10.3390/metabo13040516 - 4 Apr 2023
Cited by 1 | Viewed by 1991
Abstract
Gymnema sylvestre is traditionally used as an herbal remedy for diabetes. The effect of Gymnema sylvestre supplementation on beta cell and hepatic activity was explored in an alloxan-induced hyperglycemic adult rat. Animals were made hyperglycemic via a single inj. (i.p) of Alloxan. Gymnema sylvestre [...] Read more.
Gymnema sylvestre is traditionally used as an herbal remedy for diabetes. The effect of Gymnema sylvestre supplementation on beta cell and hepatic activity was explored in an alloxan-induced hyperglycemic adult rat. Animals were made hyperglycemic via a single inj. (i.p) of Alloxan. Gymnema sylvestre was supplemented in diet @250 mg/kg and 500 mg/kg b.w. Animals were sacrificed, and blood and tissues (pancreas and liver) were collected for biochemical, expression, and histological analysis. Gymnema sylvestre significantly reduced blood glucose levels with a subsequent increase in plasma insulin levels in a dosage-dependent manner. Total oxidant status (TOS), malondialdehyde, LDL, VLDL, ALT, AST, triglyceride, total cholesterol, and total protein levels were reduced significantly. Significantly raised paraoxonase, arylesterase, albumin, and HDL levels were also observed in Gymnema sylvestre treated hyperglycemic rats. Increased mRNA expression of Ins-1, Ins-2, Gck, Pdx1, Mafa, and Pax6 was observed, while decreased expression of Cat, Sod1, Nrf2, and NF-kB was observed in the pancreas. However, increased mRNA expression of Gck, Irs1, SREBP1c, and Foxk1 and decreased expression of Irs2, ChREBP, Foxo1, and FoxA2 were observed in the liver. The current study indicates the potent effect of Gymnema sylvestre on the transcription modulation of the insulin gene in the alloxan-induced hyperglycemic rat model. Enhanced plasma insulin levels further help to improve hyperglycemia-induced dyslipidemia through transcriptional modulation of hepatocytes. Full article
(This article belongs to the Special Issue The Role of Phytonutrients in Metabolic Disorders)
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16 pages, 3860 KiB  
Article
Anti-Diabetic and Cytotoxic Evaluation of Phlomis stewartii Plant Phytochemicals on Cigarette Smoke Inhalation and Alloxan-Induced Diabetes in Wistar Rats
by Mamoon Ur Rasheed, Syed Ali Raza Naqvi, Nasir Rasool, Syed Adnan Ali Shah and Zainul Amiruddin Zakaria
Metabolites 2022, 12(11), 1133; https://doi.org/10.3390/metabo12111133 - 17 Nov 2022
Cited by 4 | Viewed by 1804
Abstract
The generation of free radicals in body causes oxidative stress and consequently different metabolic disorders. There are numerous environmental and emotional factors that trigger free radical generation, cigarette smoke (CS) is one of them. In addition to free radical production, it also increases [...] Read more.
The generation of free radicals in body causes oxidative stress and consequently different metabolic disorders. There are numerous environmental and emotional factors that trigger free radical generation, cigarette smoke (CS) is one of them. In addition to free radical production, it also increases the risk of developing type II diabetes, cancer, and has adverse effects on other organs such as liver and kidneys. In the present study, extracts of leaves, flower, and whole plant of P. stewartii Hf. in methanol were analyzed using LC-ESI-MS and investigated for their cytotoxic properties against HepG2 cell line and CS alloxan-induced diabetes in Wistar albino rats model. A total of 24 rats were kept in aerated cage for eight weeks and exposed to CS following the administration of single dose of alloxan@140 mg/kg body weight at the end of six weeks to induce diabetes mellitus (DM). The cytotoxic activity of extracts against HepG2 was recorded in the order; leaves methanol (LM) > flower methanol (FM) and whole plant methanol (WPM). The IC50(1/4) values were in the order of 187 (LM) > 280 (FM) > 312 (WPM) µg/mL against HepG2. In positive control group, CS- and alloxan-induced diabetes significantly increased (p < 0.05) the level of alanine alkaline phosphatase (ALP), aminotransferase (ALT), aspartate aminotransferase (AST), low density lipoprotein (LDL), bilirubin, total protein, creatinine, uric acid, blood urea, globulin, total oxidant status (TOS), and malondialdehyde (MDA), as compared to negative control group. In conclusion, according to the results of this study, P. Stewartii methanol extracts showed good antioxidant, anticancer activity and worked well to recover the tested clinical parameters in CS/alloxan-induced diabetes animals, which indicated the extracts also possess good antidiabetic, hepatoprotective, and nephroprotective potential. Full article
(This article belongs to the Special Issue The Role of Phytonutrients in Metabolic Disorders)
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