Metabolic Syndrome and Non-Alcoholic Liver Disease—Second Edition

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 518

Special Issue Editor


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Guest Editor
Internal Medicine Department, University of Medicine and Pharmacy of Craiova, Filantropia Hospital of Craiova, 200143 Craiova, Romania
Interests: metabolic syndrome; non-alcoholic liver disease; insulin resistance; fatty liver disease; obesity; type 2 diabetes; liver cirrhosis; dyslipidemia; NAFLD treatment; risk factors
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Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a platform for researchers to present their latest findings and insights in the field of metabolic syndrome and non-alcoholic liver disease (NAFLD). The focus of this Special Issue is on exploring the complex interplay between metabolic syndrome and NAFLD, shedding light on its underlying mechanisms, clinical implications, and potential therapeutic strategies. 

This Special Issue welcomes contributions that address various aspects of metabolic syndrome and NAFLD, including (but not limited to) pathophysiology, epidemiology, diagnostic tools, treatment modalities, and preventive measures. Research articles, reviews, and original studies that elucidate the link between metabolic syndrome and NAFLD, as well as those focusing on novel approaches for managing these interconnected conditions, are encouraged. 

The purpose of this Special Issue is to foster a deeper understanding of the relationship between metabolic syndrome and NAFLD, considering the escalating global burden of both conditions. By gathering diverse perspectives and cutting-edge research findings, we aim to enhance our knowledge base and provide valuable insights for clinicians, researchers, and public health practitioners. Ultimately, we strive to facilitate the development of more effective strategies for the prevention, diagnosis, and management of metabolic syndrome and NAFLD, addressing the unmet clinical needs in this field. 

Potential authors are invited to contribute original research articles, reviews, and commentaries that delve into the intricate links between metabolic syndrome and NAFLD, as well as those that propose innovative approaches for addressing these significant health challenges. We welcome submissions that offer new perspectives, present compelling data, and contribute to advancing the field's understanding of metabolic syndrome and NAFLD. Through this Special Issue, we aim to encourage dialog, share best practices, and pave the way for improved clinical outcomes in these interconnected domains.

Prof. Dr. Mircea-Catalin Fortofoiu
Guest Editor

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Keywords

  • metabolic syndrome
  • non-alcoholic fatty liver disease (NAFLD)
  • insulin resistance
  • obesity
  • type 2 diabetes
  • liver cirrhosis
  • dyslipidemia
  • NAFLD treatment
  • hepatic steatosis
  • cardiovascular risk

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Published Papers (1 paper)

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Review

22 pages, 733 KB  
Review
Diagnosis and Management of Pediatric Non-Alcoholic Fatty Liver Disease: An Overview
by Dalia Dop, Vlad Pădureanu, Rodica Pădureanu, Carmen Elena Niculescu, Ștefan Adrian Niculescu and Iulia Rahela Marcu
Metabolites 2025, 15(12), 792; https://doi.org/10.3390/metabo15120792 - 12 Dec 2025
Viewed by 271
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common pediatric chronic liver disease worldwide, with an increasing prevalence, mainly due to the increase in childhood obesity and sedentary lifestyle. The pathogenesis of NAFLD is multifactorial, but the mechanisms by which the factors involved, [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is the most common pediatric chronic liver disease worldwide, with an increasing prevalence, mainly due to the increase in childhood obesity and sedentary lifestyle. The pathogenesis of NAFLD is multifactorial, but the mechanisms by which the factors involved, namely the genetic, intrauterine and environmental factors responsible for its onset and progression to NASH, are not fully known. Children with NAFLD are usually asymptomatic or show nonspecific symptoms, and NAFLD is generally diagnosed incidentally by screening tests in overweight or obese children. NAFLD is associated with severe metabolic deficiencies that may progress to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Current treatment of NAFLD in children consists of lifestyle changes to decrease caloric intake and increase physical activity, with no currently approved pharmacological medication for the pediatric population. Although pediatric studies that focus on alternative treatments targeting key pathogenic factors are promising, no pharmacological agent is currently approved for children, validated non-invasive fibrosis biomarkers remain limited, and long-term outcome data are scarce. Further validation through large prospective pediatric cohorts and phase III trials is urgently needed. Full article
(This article belongs to the Special Issue Metabolic Syndrome and Non-Alcoholic Liver Disease—Second Edition)
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