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Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes

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A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 6419

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Special Issue Editors

Dr. Alex Castro

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Guest Editor

Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, Brazil
Interests: exercise physiology; exercise; physical activity; aging; metabolomics; omic sciences; lipidomics; cardiorespiratory fitness; endurance training; high-intensity interval training; bioenergetics; nuclear magnetic resonance

Prof. Dr. Mara Patrıcia Traina Chacon-Mikahi

E-Mail Website
Guest Editor

School of Physical Education, University of Campinas, Campinas 13083-851, Brazil
Interests: cardiovascular physiology; exercise; aerobic and combined physical training; aging; hypertension; physiological adaptation; molecular adaptation; metabolic adaptation

Special Issue Information

Dear Colleagues,

Physical exercise promotes several physical and mental benefits to the human body and plays an important role in the prevention of chronic diseases. The effects of exercise are mediated by a complex process that involves the activation of integrated body systems at the molecular and cellular levels. The increasing use of metabolomics technologies in this field has allowed researchers to investigate the impact of exercise on the body through analyzing metabolites released by tissues such as skeletal muscle, bone and liver into blood, saliva, urine and sweat. Therefore, metabolomics approaches have contributed to a very comprehensive metabolic picture, enabling a more complete and accurate identification of the underlying mechanisms, pathways and biomarkers involved in disease; helping to assess therapeutic efficacy; and design personalized exercise programs for optimal health and performance, as well as for the prevention and treatment of metabolic disorders. Thus, in this Special Issue, researchers are encouraged to submit manuscripts (original research, reviews, mini reviews and perspective articles) based on metabolomic approaches, focusing on acute and chronical changes caused by exercise, as well as the combination of physical exercise with other therapies (nutrition and medication), in individuals with or without morbidities, athletes and individuals of different sex, race, ethnicity and/or region

Dr. Alex Castro
Prof. Dr. Mara Patrıcia Traina Chacon-Mikahi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

metabolome
metabolites
exercise
physical activity
metabolic signatures

Published Papers (4 papers)

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Research

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13 pages, 1179 KiB

Open AccessArticle

A Decrease in Branched-Chain Amino Acids after a Competitive Male Professional Volleyball Game—A Metabolomic-Based Approach

by Taillan Martins Oliveira, Tathiany Jéssica Ferreira, Paula Albuquerque Penna Franca, Rudson Ribeiro da Cruz, Mauricio Gattás Bara-Filho, Fábio Luiz Candido Cahuê, Ana Paula Valente and Anna Paola Trindade Rocha Pierucci

Metabolites 2024, 14(2), 115; https://doi.org/10.3390/metabo14020115 - 09 Feb 2024

Viewed by 1534

Abstract

A competitive volleyball game is a highly metabolic and physically demanding event for professional players. This study aimed to investigate whether a single game at the end of a preseason promotes changes in the biochemical markers of physical exercise responses and the metabolomic profile of professional volleyball players. This cross-sectional study included 13 male Brazilian professional volleyball players. Food intake, body composition, heart rate, physical movement variables, and blood biochemical indicators were evaluated. For non-target metabolomic analysis, serum samples were subjected to 500 MHz Nuclear Magnetic Resonance. Data analysis showed no significant difference in the biochemical indicators after the game (p > 0.05). The level of metabolites present in the groups of the main components (β-hydroxybutyrate, arginine/lysine, isoleucine, leucine, and valine) had decreased after the game. However, formic acid and histidine levels increased. Among the compounds not part of the main components, hypoxanthine and tyrosine increased, whereas low-density lipoprotein and very low-density lipoprotein levels decreased. After the game, the metabolomic profiles of players showed significant negative variations in essential amino acids (leucine, valine, and isoleucine). These decreases might be influenced by athlete diet and reduced glycogen storage due to lower carbohydrate intake, potentially impacting serum-essential amino acid levels via oxidation in skeletal muscle. The study provides insights for developing metabolic compensation strategies in athletes. Full article

(This article belongs to the Special Issue Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes)

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17 pages, 1239 KiB

Open AccessArticle

How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress

by Olina Dudašova Petrovičova, Ivan Stanković, Brižita Ðordević, Violeta Dopsaj, Neda Milinković and Milivoj Dopsaj

Metabolites 2023, 13(12), 1200; https://doi.org/10.3390/metabo13121200 - 17 Dec 2023

Viewed by 1100

Abstract

A randomized, double-blind, placebo-controlled study was conducted to investigate the influence of supplementation with a superoxide dismutase (SOD)-rich plant extract on markers of oxidative stress, zonulin levels and the performance of elite athletes. Participants were 30 international-level rowers, divided into an experimental group (n = 15) and a control group (n = 15). The rowers performed a maximal effort incremental test on a rowing ergometer at the beginning and at the end of the study. Markers of oxidative stress (total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), sulfhydryl (SH) groups, bilirubin, uric acid, albumin and zonulin) were determined in serum. A lower TOS (p = 0.010) and OSI (p = 0.004), a lower MDA (p = 0.001) and a higher level of SH groups (p = 0.031) were observed in the experimental group after supplementation. Physical performance was evaluated through metabolic efficiency, taking lactate levels and power output on the ergometer into account. After 6 weeks of supplementation, the relative increase in metabolic efficiency at a 4 mmol/L lactate concentration and maximal effort was significantly higher in the experimental group (p = 0.004 and p = 0.015, respectively). These results suggest that supplementation with a SOD-rich extract promotes lower oxidative stress, better antioxidant protection and, consequently, the better work performance of athletes. Full article

(This article belongs to the Special Issue Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes)

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Figure 1

18 pages, 1794 KiB

Open AccessArticle

Training-Induced Increase in

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O_2max and Critical Power, and Acceleration of

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O₂ on-Kinetics Result from Attenuated P_i Increase Caused by Elevated OXPHOS Activity

by Bernard Korzeniewski

Metabolites 2023, 13(11), 1111; https://doi.org/10.3390/metabo13111111 - 27 Oct 2023

Viewed by 1094

Abstract

Computer simulations using a dynamic model of the skeletal muscle bioenergetic system, involving the P_i-double-threshold mechanism of muscle fatigue, demonstrate that the training-induced increase in

\overset{\cdot}{V}

O_2max, increase in critical power (CP) and acceleration of primary phase II [...] Read more.

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O_2max, increase in critical power (CP) and acceleration of primary phase II of the

\overset{\cdot}{V}

O₂ on kinetics (decrease in t_0.63) is caused by elevated OXPHOS activity acting through a decrease in and slowing of the P_i (inorganic phosphate) rise during the rest-to-work transition. This change leads to attenuation of the reaching by P_i of Pi_peak, peak P_i at which exercise is terminated because of fatigue. The delayed (in time and in relation to

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O₂ increase) P_i rise for a given power output (PO) in trained muscle causes P_i to reach Pi_peak (in very heavy exercise) after a longer time and at a higher

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O₂; thus, exercise duration is lengthened, and

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O_2max is elevated compared to untrained muscle. The diminished P_i increase during exercise with a given PO can cause P_i to stabilize at a steady state less than P_ipeak, and exercise can continue potentially ad infinitum (heavy exercise), instead of rising unceasingly and ultimately reaching Pi_peak and causing exercise termination (very heavy exercise). This outcome means that CP rises, as the given PO is now less than, and not greater than CP. Finally, the diminished P_i increase (and other metabolite changes) results in, at a given PO (moderate exercise), the steady state of fluxes (including

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O₂) and metabolites being reached faster; thus, t_0.63 is shortened. This effect of elevated OXPHOS activity is possibly somewhat diminished by the training-induced decrease in Pi_peak. Full article

(This article belongs to the Special Issue Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes)

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Review

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21 pages, 1203 KiB

Open AccessReview

Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy

by Ana Carolina Rosa da Silva, Anahita Yadegari, Velislava Tzaneva, Tarushika Vasanthan, Katarina Laketic, Jane Shearer, Shannon A. Bainbridge, Cory Harris and Kristi B. Adamo

Metabolites 2023, 13(12), 1178; https://doi.org/10.3390/metabo13121178 - 29 Nov 2023

Cited by 1 | Viewed by 2011

Abstract

Physical activity (PA) and exercise have been associated with a reduced risk of cancer, obesity, and diabetes. In the context of pregnancy, maintaining an active lifestyle has been shown to decrease gestational weight gain (GWG) and lower the risk of gestational diabetes mellitus (GDM), hypertension, and macrosomia in offspring. The main pathways activated by PA include BCAAs, lipids, and bile acid metabolism, thereby improving insulin resistance in pregnant individuals. Despite these known benefits, the underlying metabolites and biological mechanisms affected by PA remain poorly understood, highlighting the need for further investigation. Metabolomics, a comprehensive study of metabolite classes, offers valuable insights into the widespread metabolic changes induced by PA. This narrative review focuses on PA metabolomics research using different analytical platforms to analyze pregnant individuals. Existing studies support the hypothesis that exercise behaviour can influence the metabolism of different populations, including pregnant individuals and their offspring. While PA has shown considerable promise in maintaining metabolic health in non-pregnant populations, our comprehension of metabolic changes in the context of a healthy pregnancy remains limited. As a result, further investigation is necessary to clarify the metabolic impact of PA within this unique group, often excluded from physiological research. Full article

(This article belongs to the Special Issue Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes)

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