Gut Microbiota and Nutrient Metabolism Interactions in Metabolic Syndrome and Obesity

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1440

Special Issue Editors


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Guest Editor
School of Medicine, University of California Davis, Sacramento, CA 95817, USA
Interests: nutrition; gut microbiota; diabetes; obesity; bariatric surgery; xenometabolites; inflammation

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Guest Editor
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia
Interests: cardiac energetics; gut microbiome metabolism; mitochondrial function; insulin resistance; diabetes; obesity
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Special Issue Information

Dear Colleagues,

While the differences in gut microbiota composition and functionality observed in obesity and metabolic syndrome are well documented, the actual impact of these differences on the development and progression of these conditions remains less understood. This Special Issue will provide a comprehensive overview of how the gut microbiota and nutrient metabolism act on the host’s physiology and how they can be leveraged against obesity and metabolic syndrome. Key topics will include the bidirectional interactions between the host’s gut and metabolic systems, the role of microbiota- and diet-derived xeno-metabolites, and evaluations of novel gut-centered therapeutic strategies and dietary interventions. This Special Issue will also emphasize clinical implications, predictive modeling, and personalized medicine approaches, with the aim of optimizing metabolic outcomes based on individual gut microbiota profiles. By gathering cutting-edge research works, we can advance our understanding of the field of gut microbiota–nutrient metabolism interplay and its significant implications in metabolic health.

Dr. Jean Debédat
Dr. Yen Chin Koay
Guest Editors

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Keywords

  • microbiota
  • personalized medicine
  • nutrition
  • dietary intervention
  • xenometabolites
  • obesity
  • metabolic syndrome
  • diabetes
  • gut

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Published Papers (1 paper)

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Research

26 pages, 2985 KiB  
Article
Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults
by Glauber Pimentel Florêncio, Analicy Rodrigues Xavier, Ana Catarina de Castro Natal, Lorena Prado Sadoyama, Geórgia das Graças Pena, Ralciane de Paula Menezes, Geraldo Sadoyama Leal, Lislei Jorge Patrizzi and Denise Von Dolinger de Brito Röder
Metabolites 2025, 15(2), 70; https://doi.org/10.3390/metabo15020070 - 23 Jan 2025
Cited by 1 | Viewed by 1137 | Correction
Abstract
Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight the role of intestinal bacteria in the pathophysiology of obesity. So, the objective of this study was to investigate whether [...] Read more.
Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight the role of intestinal bacteria in the pathophysiology of obesity. So, the objective of this study was to investigate whether the use of probiotics, together with healthy lifestyle habits, contributes to weight reduction in obese individuals by analyzing the intestinal microbiota profile. Methods: A prospective study was carried out with 45 adults with obesity. Participants underwent guidance on healthy lifestyle habits, received a probiotic component containing different microbiological strains and were followed for 60 days. Clinical parameters, body composition, biochemical analysis, and intestinal microbiota assessment were performed before and after treatment. After 60 days, it was observed that the bacterial strains present in the probiotic were present in the patients’ intestinal microbiota. Participants also showed improvements in physical activity, sleep quality, and anxiety management, as well as changes in some eating habits, such as a reduction in the consumption of processed foods and a significant increase in water intake. Results: A reduction in BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol, and triglycerides was observed, in addition to an increase in HDL cholesterol, improvement in bowel movement frequency, and stool consistency. Analysis of the intestinal microbiota revealed an increase in microbial diversity and a better balance between the bacterial phyla Firmicutes and Bacteroidetes. Conclusions: The changes related to improving the composition of the intestinal microbiota, dietary habits, increased physical activity, reduced anxiety, and better sleep quality have significantly contributed to weight loss and improvements in physiological parameters in obese individuals. Full article
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