Lipidomic Signatures in Pediatric Metabolic Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 856

Special Issue Editor


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Guest Editor
Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
Interests: lipidomics; metabolomics; bile acids; mass spectrometry; liquid chromatography; gas chromatography; pediatric metabolic disorders; statistics
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Special Issue Information

Dear Colleagues,

Lipids play critical roles in structural compartmentalization (barrier function), energy storage, and signal transduction, serving as key pathophysiological mediators that regulate intracellular functions, comprising apoptosis, inflammation, proliferation, and response to stress. Today, dyslipidemia is associated with multiple congenital metabolic diseases with multidisciplinary clinical appearances, including ophthalmological, neurological, renal, dermatological, orthopedic, skeletal, immune, and hepatic presentations. New lipidomic technologies and studies will allow for the identification of rare diseases in the next few years.

In recent years, different pathologies have been raised in children in industrialized countries, making the pediatric population the subject of new lines of research for understanding subsequent treatment options for providing patients with a better quality of life in the future. Some of the studied pathologies are diabetes, non-alcoholic fatty liver, and obesity. Lifestyle and dietary changes are influencing the development of these pathologies. However, other rare metabolic disorders that could not be considered in previous years are also being studied, though their metabolic pathways could be assessed based on the recent advances in analytical techniques, such as lipidomic analysis performed via mass spectrometry.

The scope of this Special Issue “Lipidomic Signatures in Pediatric Metabolic Disorders” covers topics that include lipidomic studies of the pediatric population, which can comprise, but are not limited to, new analyses, profiling, and therapies that affect and involve lipids.     

Dr. Mónica Narváez-Rivas
Guest Editor

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Keywords

  • lipidomics
  • lipids
  • mass spectrometry
  • pediatric population
  • therapeutic targets
  • biomarkers
  • metabolic disorder

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Published Papers (1 paper)

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Review

20 pages, 2431 KB  
Review
Advancing Clinical and Pathophysiological Insights into Pancreatitis Using Lipidomics and Metabolomics
by Faizan Ahmed, Xueheng Zhao, Kenneth D. R. Setchell and Maisam Abu-El-Haija
Metabolites 2025, 15(10), 666; https://doi.org/10.3390/metabo15100666 (registering DOI) - 12 Oct 2025
Viewed by 335
Abstract
Acute pancreatitis (AP) and chronic pancreatitis (CP) are distinct inflammatory conditions with significant clinical burden, including associated complications and mortality. These pancreatic conditions share overlapping pathophysiologic features. Although AP can be followed by recurrent episodes (recurrent acute pancreatitis, RAP), most CP does not [...] Read more.
Acute pancreatitis (AP) and chronic pancreatitis (CP) are distinct inflammatory conditions with significant clinical burden, including associated complications and mortality. These pancreatic conditions share overlapping pathophysiologic features. Although AP can be followed by recurrent episodes (recurrent acute pancreatitis, RAP), most CP does not follow a simple linear progression from AP; rather, CP reflects sustained processes causing injury to the pancreas (e.g., toxic-metabolic, genetic, obstructive), leading to fibrosis and organ dysfunction. Lipidomics and metabolomics can provide insights into the pathophysiology of the disease. Although researchers have extensively explored lipids and metabolites to better understand disease mechanisms, comprehensive detailed insights into the pathways and intricate roles these molecules play in pancreatitis remain unidentified. This gap can be partially attributed to limited availability of human samples from disease subgroups in pancreatitis, and current technological constraints in analytical methods, particularly regarding complete lipid and metabolite detection, identification, and quantification. In this review, we summarize lipidomic and metabolomic workflows in the context of understanding pancreatitis pathophysiology, including their design and analytical strategies. We also highlight clinical studies on pancreatitis, utilizing lipidomics and metabolomics as a tool to identify altered or dysregulated lipids or metabolites, and their association with the disease state and its progression. Full article
(This article belongs to the Special Issue Lipidomic Signatures in Pediatric Metabolic Disorders)
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