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Metabolites
Special Issues
Food Intake and Bioactive Metabolism in Humans
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Food Intake and Bioactive Metabolism in Humans

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 658

Special Issue Editors

Dr. Anallely López-Yerena

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Guest Editor
Institut Recerca Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Interests: bioactive compounds; functional foods; metabolism; bioavailability; cardiovascular diseases; lipids
Dr. Emily P. Laveriano Santos

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Guest Editor
Global Health Institute (ISGlobal), Doctor Aiguader 88, 08003 Barcelona, Spain
Interests: bioactive compounds; metabolomic; exposome; cardiometabolic; early-life outcomes

Special Issue Information

Dear Colleagues,

We are delighted to announce a special issue of Metabolites entitled "Food Intake and Bioactive Metabolism in Humans" and invite researchers and experts to contribute research articles, review articles and short communications. This special issue will explore the complex and dynamic interplay between food intake, metabolism of bioactive compounds and their impact on human health.

The focus of this special issue includes but is not limited to

  • Identification and characterization of bioactive compounds in food.
  • Mechanisms of bioactive metabolism, including interactions with the gut microbiota.
  • Bioavailability challenges and strategies to enhance bioavailability.
  • Physiological and therapeutic effects of bioactive compounds (e.g. antioxidant, anti-inflammatory, gut health).
  • Personalized nutritional approaches integrating genetics, microbiota diversity and lifestyle factors.

Bioactive compounds, including polyphenols, carotenoids, flavonoids, glucosinolates, probiotics and prebiotics, play a crucial role in health promotion and disease prevention. Once ingested, bioactive compounds are metabolized in the liver or converted by gut microbiota into active forms or excretable metabolites. However, their bioavailability is often low, influenced by factors such as age, genetic variation and microbiota diversity. Therefore, understanding their metabolism and optimizing their use in functional foods and dietary interventions remains a critical challenge.

Join us in advancing the field by submitting cutting-edge research addressing these exciting topics.  We look forward to receiving your valuable contributions!

Dr. Anallely López-Yerena
Dr. Emily P. Laveriano Santos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • phytochemical
  • carotenoids
  • polyphenols
  • oxylipins
  • gut microbiota
  • bioavailability
  • personalized nutrition
  • functional foods
  • disease prevention

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

20 pages, 1443 KiB  
Article
Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial
by Anna L. Chien, Hua Liu, Saleh Rachidi, Jessica L. Feig, Ruizhi Wang, Kristina L. Wade, Katherine K. Stephenson, Aysegul Sevim Kecici, Jed W. Fahey and Sewon Kang
Metabolites 2025, 15(6), 360; https://doi.org/10.3390/metabo15060360 - 29 May 2025
Viewed by 438
Abstract
Background/Objectives: Oxidative stress plays a pivotal role in skin aging and carcinogenesis. Phytochemicals such as sulforaphane (SF, from broccoli sprouts or seeds) or curcumin (CUR, from turmeric) can be highly protective against this stress. They each induce a suite of cytoprotective and antioxidant [...] Read more.
Background/Objectives: Oxidative stress plays a pivotal role in skin aging and carcinogenesis. Phytochemicals such as sulforaphane (SF, from broccoli sprouts or seeds) or curcumin (CUR, from turmeric) can be highly protective against this stress. They each induce a suite of cytoprotective and antioxidant enzymes that are coordinately transcribed via the Keap1-Nrf2-ARE pathway in mammals, such as the prototypical cytoprotective enzyme NAD(P)H dehydrogenase 1 (NQO1). Methods: Eighteen healthy human volunteers (9 males, 9 females, aged 18–69. were randomized to receive daily glucoraphanin (GR), which is converted to SF upon ingestion (450 mg; 1 mmol), CUR (1000 mg; 2.7 mmol), or both (450 mg GR + 1000 mg CUR), as oral supplements. After 8 days of a diet low in both compounds, blood and urine were collected for compliance and biomarker measurements. Randomized spots on the buttock’s skin were exposed to 2 x M.E.D. of UVB, and punch biopsies were obtained 1 and 3 days later for biomarker and histological measurement. Erythema was measured with a chromameter daily for 3 consecutive days following UVB. The process was repeated after receiving oral supplements, both with and without UVB exposure. Results: Compared to baseline, each treatment (n = 6 for each) induced NQO1 mRNA levels in skin biopsies: 3.1-fold with GR, 3.3-fold with CUR, and 3.6-fold with the combination of GR and CUR. Across all treatments (n = 18), expression of the pro-inflammatory cytokines IL-1β and TNF-α were reduced, as were IL-6, IL-17, STING, and CYR61, though less robustly. Modulation of these biomarkers persisted, but was less pronounced, in biopsies taken following UV exposure. The presence of SF and its metabolites in the skin post-treatment was confirmed by examining 6 of 12 subjects who ingested GR. Supplement effects on erythema following UV exposure were not significant, and no significant changes were measured in the same biomarkers in blood cells (PBMC), or by counting dyskeratotic keratinocytes. Supplements were well tolerated and compliance was excellent. Conclusions: Oral GR and CUR are well tolerated and have for the first time been shown to result in increased expression of cytoprotective genes and reduced expression of inflammatory cytokine genes in human skin in vivo. This mechanism-based clinical study suggests that an antioxidant, anti-inflammatory, and cytoprotective benefit from these oral supplements is delivered to the skin in humans. Full article
(This article belongs to the Special Issue Food Intake and Bioactive Metabolism in Humans)
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