Metabolic Change Regulated by Heavy Metals
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Environmental Metabolomics".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 116
Special Issue Editors
Interests: oxidative stress and redox imbalance in toxicological models; protective effects of natural and synthetic compounds against metal-induced damage; cellular and molecular mechanisms of toxicity; oxidative stress and mitochondrial dysfunction; metabolic alterations induced by heavy metals and environmental pollutants
Interests: experimental toxicology and reproductive toxicology; cellular and mo-lecular mechanisms of heavy metal toxicity; epididymal function and sperm maturation under toxicant exposure; metabolic alterations in-duced by environmental contaminants; epididymal function and sperm maturation under toxicant exposure
Special Issues, Collections and Topics in MDPI journals
Interests: histophysiology of reproductive and cardiovascular systems under toxicant exposure; gene and protein expression in response to environmental contaminants; developmental and prenatal exposure to heavy metals; interactions between heavy metals and metabolic diseases
Special Issue Information
Dear Colleagues,
Heavy metals are ubiquitous pollutants that interfere with cellular and systemic metabolism. Toxic metals, including cadmium, lead, mercury, nickel, chromium and arsenic, act as modulators of metabolic signaling, influencing mitochondrial bioenergetics, oxidative stress responses, osmotic balance and lipid and amino acid metabolism. Prolonged exposure to such metals disrupts metabolic homeostasis in multiple organs, including the liver, brain, kidneys, endocrine glands and gonads, contributing to degenerative processes.This Special Issue seeks to provide an integrative and current overview of how heavy metals regulate metabolic pathways at the molecular, cellular and systemic levels. Original research and reviews exploring mechanisms of metabolic regulation, identifying biomarkers of toxicity and proposing potential therapeutic strategies to neutralize or mitigate these metabolic damages are welcome. Papers utilizing multiomics approaches, as well as those investigating antioxidants, anti-inflammatories, or metabolic modulators as protective interventions, are particularly encouraged. By bringing together interdisciplinary contributions, this issue seeks to advance our understanding of dysfunctions, metabolic adaptations and potential treatments associated with heavy metal exposure, offering new insights for mechanistic toxicology and preventive medicine.
Dr. Luiz Otávio Guimaraes-Ervilha
Dr. Mariana Machado Neves
Dr. Ana Cláudia Ferreira Souza
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heavy metals
- metal-induced toxicity
- mitochondrial bioenergetics
- redox signaling
- oxidative stress
- metal homeostasis
- detoxification pathways
- metallothioneins
- multiomics
- therapeutic interventions
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