Newest Pharmacology Findings in Cardiovascular Diseases

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1173

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Department of Pharmacology and Clinical Pharmacology, Comenius University Bratislava, Bratislava, Slovakia
Interests: pharmacology; clinical pharmacology; cardiovascular; neuronal system; orthopaedic
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Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) remain a leading cause of death globally, necessitating continuous innovation in treatment and prevention. This special issue focuses on the emerging trends transforming cardiovascular pharmacology, highlighting the latest research and breakthroughs. We invite submissions exploring novel drug targets and mechanisms, such as inflammation and RNA therapeutics.

Additionally, we seek contributions to individual medicine advancements like genetic profiling and biomarker-guided therapy. Manuscripts are encouraged to discuss drug repurposing, combination therapies, and technological innovations like wearable devices and AI in drug discovery. Finally, we welcome research on public health initiatives and lifestyle interventions for CVD prevention. This issue aims to advance the field and improve patient outcomes by showcasing these cutting-edge developments.

Dr. Andrea Gažová
Guest Editor

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Keywords

  • cardiovascular pharmacology
  • drug targets
  • inflammation
  • RNA therapeutics
  • precision medicine
  • genetic profiling
  • biomarkers
  • drug repurposing
  • wearable devices
  • artificial intelligence

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Published Papers (1 paper)

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Research

14 pages, 18158 KiB  
Article
Preclinical Evaluation of the Anticoagulant Effect of an Aqueous Extract of Snow Mountain Garlic
by Isabel Clark-Montoya, Rosa del Carmen Milán-Segovia, Obed Lemus-Rojero, Osmar Antonio Jaramillo-Morales, Bertha Júarez-Flores and Yolanda Terán-Figueroa
Medicina 2025, 61(3), 429; https://doi.org/10.3390/medicina61030429 - 28 Feb 2025
Viewed by 914
Abstract
Background/Objectives: In the genus Allium, it has been shown that some organosulfate compounds of common garlic and onion have an antiplatelet effect. Still, little is known about the anticoagulant activity of the species, Allium ampeloprasum L., specifically Snow mountain garlic; due to [...] Read more.
Background/Objectives: In the genus Allium, it has been shown that some organosulfate compounds of common garlic and onion have an antiplatelet effect. Still, little is known about the anticoagulant activity of the species, Allium ampeloprasum L., specifically Snow mountain garlic; due to its growth site at 6000 m above sea level at temperatures of −10 °C, it could contain different organosulfate compounds. Methods: This study evaluated the anticoagulant effect of a lyophilized aqueous extract of S. mountain garlic in vivo, toxicity in male Wistar rats for 90 days, and the organosulfate compounds present. Results: There was a significant increase (p < 0.05) in the area under the curve for bleeding time at doses of 500 and 1000 mg/kg/d of lyophilized aqueous extract of Snow mountain garlic and 100 mg/kg/d of acetylsalicylic acid. The ED50 was 366 ± 2.43 mg/kg. For chronic toxicity in vivo, no histopathological alterations were found at doses below 500 mg/kg. On the other hand, organosulfate compounds were found in the lyophilized aqueous extract of S. mountain garlic that had not been documented to have an anticoagulant effect. Conclusions: We conclude that S. mountain garlic contains anticoagulant compounds which may be candidates for the treatment of thrombosis. Full article
(This article belongs to the Special Issue Newest Pharmacology Findings in Cardiovascular Diseases)
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