Colorectal Carcinoma: Pathologic Aspects

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2165

Special Issue Editor


E-Mail Website
Guest Editor
National Cancer Institute, 08660 Vilnius, Lithuania
Interests: minimal invasive colorectal surgery; patient functional outcomes; molecular markers in colorectal cancer diagnostics; cancer screening programs

Special Issue Information

Dear Colleagues,

Colorectal carcinoma is one of the most common cancers and one of the leading causes of cancer-related death worldwide. Pathologic examination of biopsy, polypectomy and resection specimens is crucial for correct patient management, prognosis assessment and family counseling. Molecular testing plays an increasingly important role in the era of personalized medicine. This Special Issue will focus on the histopathology and molecular pathology of colorectal carcinoma and its precursor lesions, with an emphasis on their clinical relevance.

Dr. Audrius Dulskas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathological response
  • molecular markers
  • tumor budding
  • artificial intelligence
  • colorectal cancer
  • histomorphological factors
  • lymphocytic infiltration

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

12 pages, 1992 KiB  
Article
Intratumoral Budding in Pretreatment Biopsies, among Tumor Microenvironmental Components, Can Predict Prognosis and Neoadjuvant Therapy Response in Colorectal Adenocarcinoma
by Kwangil Yim, Won Mo Jang, Uiju Cho, Der Sheng Sun, Yosep Chong and Kyung Jin Seo
Medicina 2022, 58(7), 926; https://doi.org/10.3390/medicina58070926 - 12 Jul 2022
Cited by 4 | Viewed by 1750
Abstract
Background and Objectives: The prediction of the prognosis and effect of neoadjuvant therapy is vital for patients with advanced or unresectable colorectal carcinoma (CRC). Materials and Methods: We investigated several tumor microenvironment factors, such as intratumoral budding (ITB), desmoplastic reaction (DR), and [...] Read more.
Background and Objectives: The prediction of the prognosis and effect of neoadjuvant therapy is vital for patients with advanced or unresectable colorectal carcinoma (CRC). Materials and Methods: We investigated several tumor microenvironment factors, such as intratumoral budding (ITB), desmoplastic reaction (DR), and Klintrup–Mäkinen (KM) inflammation grade, and the tumor–stroma ratio (TSR) in pretreatment biopsy samples (PBSs) collected from patients with advanced or unresectable CRC. A total of 85 patients with 74 rectal carcinomas and 11 colon cancers treated at our hospital were enrolled; 66 patients had curative surgery and 19 patients received palliative treatment. Results: High-grade ITB was associated with recurrence (p = 0.002), death (p = 0.034), and cancer-specific death (p = 0.034). Immature DR was associated with a higher grade of clinical tumor-node-metastasis stage (cTNM) (p = 0.045), cN category (p = 0.045), and cM category (p = 0.046). The KM grade and TSR were not related to any clinicopathological factors. High-grade ITB had a significant relationship with tumor regression in patients who received curative surgery (p = 0.049). Conclusions: High-grade ITB in PBSs is a potential unfavorable prognostic factor for patients with advanced CRC. Immature DR, TSR, and KM grade could not predict prognosis or therapy response in PBSs. Full article
(This article belongs to the Special Issue Colorectal Carcinoma: Pathologic Aspects)
Show Figures

Figure 1

Back to TopTop