Recent Developments in Anticancer Drug Delivery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 3105

Special Issue Editors

Special Issue Information

Dear Colleagues,

This Special Issue will bring together recent scientific advances in the field of cancer drug delivery and, in particular, the current challenges facing cancer treatments. Our improved knowledge of carcinogenesis and cell biology has led to an increase in the types of cancer treatment available in recent years. However, many cancers are still fatal, and it has been recognized that the best way to improve the survival rate of cancer patients is through the targeted delivery of anticancer drugs. These new types of formulations are characterized by their suitability for targeted delivery to specific tissues, cells, and even intracellular structures. Targeted delivery allows not only a specific effect but also a reduction in the dosage of the usually very toxic drug. The main objective of this Special Issue is to highlight the potential development of vehicles for the delivery of anticancer drugs, emphasizing the specificity of the sites of action and the possible occurrence of undesirable side effects. We are pleased to invite you to contribute to this Special Issue by submitting original articles and reviews on this topic.

We look forward to receiving your contributions.

Prof. Dr. Simone Beninati
Prof. Dr. Carlo Mischiati
Guest Editors

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Keywords

  • drug delivery
  • anticancer drugs
  • cell-targeted delivery
  • nanocarriers

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Published Papers (2 papers)

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10 pages, 1928 KiB  
Article
Targeted Suppression of CEACAM6 via pHLIP-Delivered RNAs in Pancreatic Ductal Adenocarcinoma
by Hongsik Kim, Chang-Gok Woo, Seung-Myoung Son, Yong-Pyo Lee, Hee-Kyung Kim, Yaewon Yang, Jihyun Kwon, Ki-Hyeong Lee, Ho-Chang Lee, Ok-Jun Lee and Hye-Sook Han
Medicina 2025, 61(4), 598; https://doi.org/10.3390/medicina61040598 - 26 Mar 2025
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Abstract
Background and Objectives: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is involved in pancreatic cancer progression and is an attractive therapeutic target for pancreatic cancer. In this study, we evaluated the therapeutic efficacy of small-interfering RNA (siRNA) targeting CEACAM6 (siCEACAM6) and the [...] Read more.
Background and Objectives: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is involved in pancreatic cancer progression and is an attractive therapeutic target for pancreatic cancer. In this study, we evaluated the therapeutic efficacy of small-interfering RNA (siRNA) targeting CEACAM6 (siCEACAM6) and the CEACAM6-suppressive microRNA-29a (miR-29a) in a pancreatic ductal adenocarcinoma xenograft mouse model using pH-low insertion peptide (pHLIP) technology, which targets the acidic tumor microenvironment. Materials and Methods: The delivery vectors for siRNA and miRNA were constructed by conjugating the peptide nucleic acid forms of siCEACAM6 and miR-29a to a peptide with a pHLIP, enabling the transport of siRNA and miRNA across the plasma membrane. The tumor-suppressive effects of pHLIP-siCEACAM6 and pHLIP-miR-29a were assessed in vivo using a BALB/c xenograft mouse model with the injection of the CFPAC-1 human pancreatic ductal adenocarcinoma cell line. Results: The treatment of CFPAC-1 cells with pHLIP-siCEACAM6 and pHLIP-miR-29a under acidic pH conditions suppressed CEACAM6 expression and decreased cell viability. In a xenograft mouse model, the intravenous injection of pHLIP-siCEACAM6 and pHLIP-miR-29a suppressed tumor growth by up to 25.1% (p < 0.01) and 21.2% (p < 0.01), respectively, compared to the control mice treated with pHLIP-scr. Conclusions: Our results demonstrated the efficacy of the pHLIP-mediated delivery of siCEACAM6 and miR-29a as a promising therapeutic strategy in a pancreatic ductal adenocarcinoma xenograft mouse model. The pHLIP technology, which targets the acidic tumor microenvironment, represents an innovative approach to the delivery of small RNAs to pancreatic ductal adenocarcinoma cells, providing new potential strategies for pancreatic cancer treatment. Full article
(This article belongs to the Special Issue Recent Developments in Anticancer Drug Delivery)
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Case Report
Adverse Events in Osimertinib Treatment for EGFR-Mutated Non-Small-Cell Lung Cancer: Unveiling Rare Life-Threatening Myelosuppression
by Walid Shalata, Ashraf Abu Jama, Yulia Dudnik, Omar Abu Saleh, Sondos Shalata, Lena Tourkey, Kim Sheva, Amichay Meirovitz and Alexander Yakobson
Medicina 2024, 60(8), 1270; https://doi.org/10.3390/medicina60081270 - 6 Aug 2024
Cited by 3 | Viewed by 2262
Abstract
Recent advancements in targeted therapies for non-small-cell lung cancer (NSCLC), specifically focusing on epidermal growth factor receptor (EGFR) mutations, have revolutionized treatment strategies. Osimertinib, an approved therapy for metastatic NSCLC with EGFR mutations, highlights remarkable efficacy but also harbors the potential for severe [...] Read more.
Recent advancements in targeted therapies for non-small-cell lung cancer (NSCLC), specifically focusing on epidermal growth factor receptor (EGFR) mutations, have revolutionized treatment strategies. Osimertinib, an approved therapy for metastatic NSCLC with EGFR mutations, highlights remarkable efficacy but also harbors the potential for severe adverse events, whose rarity or lack of precedence may mask their criticality. This article delves into the exploration of adverse events linked to osimertinib, shedding light on a rare yet life-threatening occurrence: severe myelosuppression. A case study detailing a patient with EGFR-mutated NSCLC exhibiting a robust treatment response but experiencing severe myelosuppression following osimertinib initiation is presented. Immediate discontinuation of osimertinib alongside concurrent blood transfusions facilitated toxicity recovery, prompting a successful reduction in myelosuppression severity upon re-administration at a lowered dosage. Full article
(This article belongs to the Special Issue Recent Developments in Anticancer Drug Delivery)
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