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Medicina
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Advances in Radical Prostatectomy
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Advances in Radical Prostatectomy

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Urology & Nephrology".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 2933

Special Issue Editor

Dr. Angelo Totaro

E-Mail Website
Guest Editor
1. Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
2. Department of Medicine and Translational Surgery, Università Cattolica Del Sacro Cuore, 00168 Rome, Italy
Interests: prostate cancer; kidney cancer; bladder cancer; UTUC; robotic surgery; uro-oncology

Special Issue Information

Dear Colleagues,

Welcome to this Special Issue on “Advances in Radical Prostatectomy”. This collection features cutting-edge research and innovations in the surgical treatment of prostate cancer. Radical prostatectomy remains a crucial intervention for localized prostate cancer, and recent years have seen remarkable progress in this field.

The transition from traditional surgical methods to robotic-assisted techniques marks a significant leap forward, offering greater precision and reduced recovery times. This Special Issue covers the latest developments in these areas, including advancements in minimally invasive procedures and nerve-sparing techniques aimed at preserving erectile function and urinary continence, which are critical for patient quality of life.

We also explore the importance of multidisciplinary approaches in enhancing treatment outcomes, highlighting the integration of advanced imaging technologies and biomarkers for improved preoperative and postoperative care. Furthermore, this Special Issue reviews current guidelines and strategies for managing complications and improving long-term survival rates.

Our contributors, experts in urology and oncology, provide invaluable insights into the challenges and future directions of radical prostatectomy. We hope this Special Issue will serve as a key resource for clinicians, researchers, and students committed to the advancement of prostate cancer treatment.

Dr. Angelo Totaro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • robotic surgery
  • robot-assisted radical prostatectomy
  • telesurgery
  • minimally invasive surgery
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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9 pages, 441 KiB  
Article
Impact of Perioperative Lidocaine on Neutrophil Extracellular Trapping and Serum Cytokines in Robot-Assisted Radical Prostatectomy: Randomized Controlled Study
by Dongho Shin, Jiheon Kim, Subin Lee and Min Suk Chae
Medicina 2024, 60(9), 1452; https://doi.org/10.3390/medicina60091452 - 5 Sep 2024
Cited by 2 | Viewed by 2164
Abstract
Background and Objective: This randomized controlled trial investigated the influence of perioperative lidocaine administration on the postoperative inflammatory response in patients undergoing robot-assisted radical prostatectomy, with the results having potential implications for postoperative recovery and cancer recurrence via neutrophil extracellular trapping (NETosis). Materials [...] Read more.
Background and Objective: This randomized controlled trial investigated the influence of perioperative lidocaine administration on the postoperative inflammatory response in patients undergoing robot-assisted radical prostatectomy, with the results having potential implications for postoperative recovery and cancer recurrence via neutrophil extracellular trapping (NETosis). Materials and Methods: In total, 58 patients with localized prostate cancer were randomly assigned to receive an intravenous infusion of 2% lidocaine or a saline placebo intraoperatively. Serum levels of interleukin (IL)-6, IL-10, and IL-17, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, neutrophil elastase (NE), citrullinated histone3 (CitH3), and myeloperoxidase (MPO) were determined preoperatively and at 24 h postoperatively. Biochemical recurrence (BCR) was assessed over a follow-up period of 2 years. Results: The lidocaine group showed a significant change in MPO, a greater reduction in IL-10 level, and a smaller increase in the NE level compared to the placebo group, suggesting a modulatory effect of lidocaine on certain anti-inflammatory and neuroendocrine pathways. No significant difference in the BCR rate was observed between the two groups. Conclusions: Perioperative lidocaine administration selectively modulates certain inflammatory and neuroendocrine responses after robot-assisted radical prostatectomy surgery, potentially influencing recovery outcomes. These findings highlight the need for further investigations of the role of lidocaine in Enhanced Recovery After Surgery protocols, particularly in oncologic surgeries. Full article
(This article belongs to the Special Issue Advances in Radical Prostatectomy)
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Review

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15 pages, 529 KiB  
Review
Advances in Techniques in Radical Prostatectomy
by Hui Miin Lau, Liang G. Qu and Dixon T. S. Woon
Medicina 2025, 61(7), 1222; https://doi.org/10.3390/medicina61071222 - 4 Jul 2025
Viewed by 421
Abstract
Since its development in 1904, radical prostatectomy (RP) has remained a fundamental surgical option in the management of localised prostate cancer. Over time, continuous advancements in surgical techniques have improved oncological outcomes while reducing functional complications. This narrative review explores the evolution of [...] Read more.
Since its development in 1904, radical prostatectomy (RP) has remained a fundamental surgical option in the management of localised prostate cancer. Over time, continuous advancements in surgical techniques have improved oncological outcomes while reducing functional complications. This narrative review explores the evolution of RP, depicting its progression from the traditional open approach to minimally invasive laparoscopic and robotic-assisted techniques. Key developments in RP techniques, including nerve-sparing, bladder neck-sparing and Retzius-sparing techniques as well as enhanced perioperative management, have contributed to reduced postoperative complications, namely incontinence and erectile dysfunction. Additionally, technological innovations such as augmented reality, utilising indocyanine green for improved visualisation of prostatic boundaries and illuminare-1 to easily identify nerves intraoperatively, artificial intelligence, and novel molecular imaging technologies such as PSMA PETs for improved margin assessment are shaping the future of RPs. Despite these advancements, challenges persist, including a steep learning curve associated with newer techniques, disparities in access due to cost considerations, and a lack of standardised outcome measures across different surgical approaches. This review provides insight into current trends, ongoing challenges, and future directions that may further refine surgical precision, enhance patient safety, and improve long-term treatment success in prostate cancer management. Full article
(This article belongs to the Special Issue Advances in Radical Prostatectomy)
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