Dear Colleagues,

The concept of biosensors has evolved enormously since 1962 when Clark and Lyons developed the first biosensor capable of measuring oxygen in blood which was the seed from where myriads of glucose sensors have blossomed. Although biosensors have often been conceived as powerful screening tools, advances in nanotechnology have been essential to re-shape their definition and scope, being today of high interest in many fields of application due to their unique advantages. The exponential increase in biosensors development and the flourishing success of their market are underpinned by their simplicity, potential miniaturisation and portability, even wearability, cost-effectiveness and rapid turn-around time, but also by the fact they can provide highly accurate, precise and reliable quantitative information.

Materials science has a key role in the contributions of nanotechnology to improve biosensors analytical performance and facilitate their design to fulfill the requirements of the end-user. The advanced development of new nanostructured transducers opens new insights in the design, characteristics and performance of optical, electrochemical and mass-sensitive biosensors, but also nanoelectromechanical biosystems. Apart from the signal enhancement achieved by using transducers of large surface area, nanostructured materials offer a wide range of possibilities in terms of engineering new sensing paradigms, single molecule detection, multiplexing capabilities and integration into portable devices, among others.

This Special Issue aims to cover recent advances in the development of nanostructure-based biosensors, with a special focus on highlighting the advantages of introducing structures at the nanoscale level in their design.

Dr. Beatriz Prieto-Simón
Dr. Maria Alba
Guest Editors

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• materials science
• biosensors
• nanotechnology
• bioengineering
• surface science