Marine Algal Bioactive Compounds for the Management of Non-communicable Chronic Diseases

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1670

Special Issue Editor


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Guest Editor
Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa
Interests: seaweeds; sulfated polysaccharides; fucoidans; carrageenan; laminarin; fucoxanthin; alginates; ulvans; polyphenols; carotenoids; obesity; type 2 diabetes; cardiovascular; metabolic disorders; hypertension
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Special Issue Information

Dear Colleagues,

Marine algae represent a viable and sustainable source for the extraction of bioactive compounds including polysaccharides, peptides, and polyphenols. These compounds have been reported to possess health benefits and have modulatory effects on many chronic metabolic diseases. The different extraction procedures and the characterization of compounds derived from marine algae have revealed a plethora of ameliorative effects  against disease parameters including antioxidant, anti-hyperglycaemic, anticoagulant, anti-inflammatory, anti-viral, anti-cancer, and immunomodulatory effects, making them ideal candidates for the development of novel therapeutics for chronic diseases.

The bioactive compounds derived from marine algae hold a great potential for the development of products with significant therapeutic and biomedical applications. Therefore, this Special Issue aims to highlight the therapeutic potential of compounds derived from marine algae on non- communicable diseases. We invite researchers to contribute original articles, reviews, and perspectives in this regard.

Prof. Dr. Shahidul Islam
Guest Editor

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Keywords

  • alginates
  • cardiovascular
  • carotenoids
  • carrageenan
  • fucoidans
  • fucoxanthin
  • hypertension
  • laminarin
  • metabolic disorders
  • obesity
  • polyphenols
  • seaweeds
  • sulfated polysaccharides
  • type 2 diabetes
  • ulvans

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Published Papers (1 paper)

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Review

20 pages, 5456 KiB  
Review
Anti-Obesity Effects of Sulphated Polysaccharides Derived from Marine Macro Algae or Seaweeds: A Systematic Review and Meta-Analysis
by S’thandiwe Nozibusiso Magwaza, Vunene Nkateko Chabalala, Nothando Philile Hlongwane, Huda Ismail and Md. Shahidul Islam
Mar. Drugs 2024, 22(12), 528; https://doi.org/10.3390/md22120528 - 25 Nov 2024
Viewed by 1315
Abstract
Sulphated polysaccharides (SPs) are negatively charged compounds found in the cell wall of seaweeds or marine macro algae. These compounds exhibit a range of pharmacological activities, including anti-obesity effects. The aim of this systematic review as well as meta-analysis was to assess the [...] Read more.
Sulphated polysaccharides (SPs) are negatively charged compounds found in the cell wall of seaweeds or marine macro algae. These compounds exhibit a range of pharmacological activities, including anti-obesity effects. The aim of this systematic review as well as meta-analysis was to assess the potentials of seaweed-derived SPs to mitigate obesity through a systematic review and meta-analysis of animal model-based studies. A comprehensive summary of the included articles was conducted, focusing on the following obesity-related parameters: food intake, body weight gain, epididymal fat size, adipocyte size, liver weight, serum alanine transaminase (ALT) and aspartate transaminase (AST), insulin and tumour necrosis factor-α (TNF-α), and the lipid profile (total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)). The systematic review demonstrated that seaweed-derived SPs exhibit ameliorative effects against obesity, as evidenced by reductions in food intake, body weight gain, epididymal fat and adipocyte size, liver weight, ALT and AST levels, serum insulin and TNF-α, LDL-c, total cholesterol, and triglycerides and an increase in HDL-c in obese rats administered with seaweed-derived SPs. However, the meta-analysis revealed statistically significant anti-obesity effects of seaweed-derived SPs for most, but not all the parameters tested. Further research in human subjects is necessary not only to ascertain the results of preclinical studies but also to provide conclusive evidence of the anti-obesity potential of SPs in humans. Full article
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