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Synthesis, Optimization and Biological Activity of Marine Natural Product

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Synthesis and Medicinal Chemistry of Marine Natural Products".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 1195

Special Issue Editors


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Guest Editor
South China Seas Institute of Oceanography, Chinese Academy of Sciences, Guangzhou, China
Interests: bioactive marine natural product discovery; synthesis; optimization; biological evaluation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Jinan, China
Interests: biomimetic total synthesis; structural derivatization; biological evaluation of natural products

Special Issue Information

Dear Colleagues,

Growing attention is being directed toward the discovery of bioactive marine natural products—compounds derived from marine plants, organisms, or microbial fermentation. Total synthesis or structural optimization is often employed to overcome limitations such as scarce natural availability or insufficient bioactivity.

To showcase outstanding research in this area, we are pleased to announce the launch of a new Special Issue, titled “Synthesis, Optimization and Biological Activity of Marine Natural Product”. This Special Issue will focus on the synthesis, structural optimization, and biological evaluation of marine-derived scaffolds. We warmly invite scientists from around the world to contribute their reviews and original research findings in this field to Marine Drugs.

Dr. Shengrong Liao
Prof. Dr. Zejun Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural product
  • synthesis
  • optimization
  • biological evaluation
  • anticancer
  • antimicrobial activity
  • design and synthesis

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Published Papers (1 paper)

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Research

12 pages, 2466 KB  
Article
Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity
by Xiao-Mei Liu, Wen-Xuan Li, Ling-Xiu Kong, Guan-Ying Han, Jinghan Gui and Xu-Wen Li
Mar. Drugs 2026, 24(1), 48; https://doi.org/10.3390/md24010048 - 20 Jan 2026
Viewed by 871
Abstract
The discovery of structurally novel anti-tumor agents remains a crucial objective in cancer drug research. In this study, we systematically explored the bioactivity potential of sarocladione (5), a structurally unique marine-derived 14-membered ring diketone steroid. Guided by a function-oriented strategy, seven [...] Read more.
The discovery of structurally novel anti-tumor agents remains a crucial objective in cancer drug research. In this study, we systematically explored the bioactivity potential of sarocladione (5), a structurally unique marine-derived 14-membered ring diketone steroid. Guided by a function-oriented strategy, seven new derivatives (613) were synthesized based on an efficient biomimetic synthesis of sarocladione. Evaluation of their antiproliferative activities against human cancer cell lines demonstrated that the intact macrocyclic scaffold is indispensable for activity. Extension of the conjugated π-system led to the identification of compound 8, which exhibited approximately four-fold enhanced potency against HCT116 cells (IC50 = 1.86 µM) compared with the parent natural product. Stereochemical analysis further revealed the critical role of the (5R)-configuration at C-5. Phenotypic investigations indicated that compound 8 induces concentration-dependent G2/M phase cell cycle arrest, followed by apoptosis, suggesting a cell cycle-dependent antiproliferative effect. Overall, this study highlights sarocladione as a promising marine-derived scaffold for further antiproliferative optimization. Full article
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