Proteomic Studies for the Characterization of the Biological Targets of Marine Bioactive Molecules

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5300

Special Issue Editor


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Guest Editor
1. School of Health and Human Sciences, Southern Cross University, Gold Coast, QLD 4225, Australia
2. Marine Ecology Research Centre, Southern Cross University, Lismore, Military Rd., East Lismore, NSW 2480, Australia
Interests: marine biology; sequencing; molecular biology; biomedical products; gene expression; genomics; molecular genetics; epigenetics
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Special Issue Information

Dear Colleagues,

The marine environment makes up to 71% of the Earth surface and is a rich source of bioactive compounds and natural medicines. Marine bioactive molecules are important in relation to drug discovery, specifically if characterized with antitumor, anti-inflammatory, antiviral, and other pharmacological activities. The potential for marine natural bio-products to be used as new drugs is still in relatively new stages of the development. The focus of this special issue is to provide updates about recent proteomics studies using marine organisms as a source of bioactive molecules and new technologies applied. The huge potential of modern next-generation high-throughput sequencing technologies in the combination with liquid chromatography–mass spectrometry, are currently advancing our understanding of protein function and genetics. This is important for the development of novel drugs, which is expending the possibilities for the discoveries and characterizations of new biomolecules for treatment of various diseases.

I invite researchers from different disciplines including chemistry, medical science, nanotechnology, biotechnology, biochemistiries and other fields to consider  making contribition to this Special Issue. I encourage my collueges to submit original research articles and review papers to update the curent body of knowledge and to promote the application of proteomics studies in providing better understanding of proteins functional role in health and diseases.

Dr. Nedeljka Rosic
Guest Editor

Manuscript Submission Information

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Keywords

  • Proteomics
  • Bioproducs
  • Marine drugs
  • Marine toxins
  • Liquid chromatography
  • Sequencing

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Published Papers (1 paper)

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Research

27 pages, 1911 KiB  
Article
Characterization of the Jumbo Squid (Dosidicus gigas) Skin By-Product by Shotgun Proteomics and Protein-Based Bioinformatics
by Mónica Carrera, Josafat Marina Ezquerra-Brauer and Santiago P. Aubourg
Mar. Drugs 2020, 18(1), 31; https://doi.org/10.3390/md18010031 - 29 Dec 2019
Cited by 25 | Viewed by 4686
Abstract
Jumbo squid (Dosidicus gigas) is one of the largest cephalopods, and represents an important economic fishery in several regions of the Pacific Ocean, from southern California in the United States to southern Chile. Large and considerable discards of this species, such [...] Read more.
Jumbo squid (Dosidicus gigas) is one of the largest cephalopods, and represents an important economic fishery in several regions of the Pacific Ocean, from southern California in the United States to southern Chile. Large and considerable discards of this species, such as skin, have been reported to constitute an important source of potential by-products. In this paper, a shotgun proteomics approach was applied for the first time to the characterization of the jumbo squid (Dosidicus gigas) skin proteome. A total of 1004 different peptides belonging to 219 different proteins were identified. The final proteome compilation was investigated by integrated in-silico studies, including gene ontology (GO) term enrichment, pathways, and networks studies. Potential new valuable bioactive peptides such as antimicrobial, bioactive collagen peptides, antihypertensive and antitumoral peptides were predicted to be present in the jumbo squid skin proteome. The integration of the global proteomics results and the bioinformatics analysis of the jumbo squid skin proteome show a comprehensive knowledge of this fishery discard and provide potential bioactive peptides of this marine by-product. Full article
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