Special Issue "Proteomic Studies for the Characterization of the Biological Targets of Marine Bioactive Molecules"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 1 July 2020.

Special Issue Editor

Dr. Nedeljka Rosic
E-Mail Website
Guest Editor
1. School of Health and Human Sciences; Southern Cross University, Gold Coast, QLD, 4225; Australia
2. Marine Ecology Research Centre, Southern Cross University, Lismore, Military Rd, East Lismore, NSW 2480, Australia
Interests: Marine Biology; Sequencing; Molecular Biology; Biomedical products, Gene Expression; Genomics; Molecular Genetics; Epigenetics

Special Issue Information

Dear Colleagues,

The marine environment makes up to 71% of the Earth surface and is a rich source of bioactive compounds and natural medicines. Marine bioactive molecules are important in relation to drug discovery, specifically if characterized with antitumor, anti-inflammatory, antiviral, and other pharmacological activities. The potential for marine natural bio-products to be used as new drugs is still in relatively new stages of the development. The focus of this special issue is to provide updates about recent proteomics studies using marine organisms as a source of bioactive molecules and new technologies applied. The huge potential of modern next-generation high-throughput sequencing technologies in the combination with liquid chromatography–mass spectrometry, are currently advancing our understanding of protein function and genetics. This is important for the development of novel drugs, which is expending the possibilities for the discoveries and characterizations of new biomolecules for treatment of various diseases.

I invite researchers from different disciplines including chemistry, medical science, nanotechnology, biotechnology, biochemistiries and other fields to consider  making contribition to this Special Issue. I encourage my collueges to submit original research articles and review papers to update the curent body of knowledge and to promote the application of proteomics studies in providing better understanding of proteins functional role in health and diseases.

Dr. Nedeljka Rosic
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Proteomics
  • Bioproducs
  • Marine drugs
  • Marine toxins
  • Liquid chromatography
  • Sequencing

Published Papers (1 paper)

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Research

Open AccessArticle
Characterization of the Jumbo Squid (Dosidicus gigas) Skin By-Product by Shotgun Proteomics and Protein-Based Bioinformatics
Mar. Drugs 2020, 18(1), 31; https://doi.org/10.3390/md18010031 - 29 Dec 2019
Abstract
Jumbo squid (Dosidicus gigas) is one of the largest cephalopods, and represents an important economic fishery in several regions of the Pacific Ocean, from southern California in the United States to southern Chile. Large and considerable discards of this species, such [...] Read more.
Jumbo squid (Dosidicus gigas) is one of the largest cephalopods, and represents an important economic fishery in several regions of the Pacific Ocean, from southern California in the United States to southern Chile. Large and considerable discards of this species, such as skin, have been reported to constitute an important source of potential by-products. In this paper, a shotgun proteomics approach was applied for the first time to the characterization of the jumbo squid (Dosidicus gigas) skin proteome. A total of 1004 different peptides belonging to 219 different proteins were identified. The final proteome compilation was investigated by integrated in-silico studies, including gene ontology (GO) term enrichment, pathways, and networks studies. Potential new valuable bioactive peptides such as antimicrobial, bioactive collagen peptides, antihypertensive and antitumoral peptides were predicted to be present in the jumbo squid skin proteome. The integration of the global proteomics results and the bioinformatics analysis of the jumbo squid skin proteome show a comprehensive knowledge of this fishery discard and provide potential bioactive peptides of this marine by-product. Full article
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