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Marine Microorganisms Bioprospecting, 2nd Edition

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Dear Colleagues,

Marine microorganisms, including bacteria, fungi, and microalgae, are recognized as important sources of pharmacologically active metabolites. Marine habitats, such as the deep sea, hydrothermal vents, cold springs, and polar regions, have led marine microorganisms to evolve unique metabolic pathways to cope with the conditions related to special environments characterized by intense competition. The utilization of bioactive compounds from marine microorganisms as health products results in a crucial advancement in the field of healthcare and wellness. With the advent of new analytical methods and multi-omics technologies, the current screening for promising natural products and their research and development in the pharmaceutical pipeline have increased. More and more new enzymatic and pharmacological mechanisms of active metabolites from marine microorganisms are expected to be revealed.

This Special Issue aims to collect papers on the most recent findings in the field of “Marine Microorganism Bioprospecting”. We are interested in new data on the collection of marine microbial resources, isolation, structural identification, modification, activity screening, and biosynthetic pathways of secondary metabolites as well as their pharmacological mechanisms. Comprehensive review papers examining the latest active compounds of marine microbial origins are also welcome.

Dr. Junfeng Wang
Dr. Qingbo Zhang
Guest Editors

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13 pages, 1749 KB

Open AccessArticle

Diverse and Bioactive Lactones from the Sri Lankan Mangrove-Derived Fungus Talaromyces sp. SCSIO41445

by Parakkrama Wijerathna, Xinqi Chen, Yi Chen, Yufan Zhang, Jian Cai, Mengjing Cong, Ying Liu, Lalith Jayasinghe, Yonghong Liu, Disna Ratnasekera and Xuefeng Zhou

Mar. Drugs 2026, 24(2), 80; https://doi.org/10.3390/md24020080 - 14 Feb 2026

Viewed by 565

Abstract

Three previously uncharacterized lactones, namely penicianstinoid L (1), talaromyketide J (2) and peniciisocoumarin K (3), along with twenty-eight known compounds (4–31), were yielded from the mangrove-derived fungus Talaromyces sp. SCSIO41445, collected from Mangrove Park (NARA), Sri Lanka. Their structures were established by HRESIMS and NMR spectroscopic analysis (including ¹H and ¹³C NMR, HSQC, and HMBC), with the stereostructures of 2 and 3 being confirmed by single-crystal X-ray crystallographic analysis. Furthermore, compounds 1–31 were evaluated in terms of their neuraminidase (NA) inhibitory activities. These bioassay results revealed that three lactones (11, 15, and 16) of them exerted NA inhibitory effects, with IC₅₀ values of 46.66 ± 2.31, 20.78 ± 1.89, and 34.14 ± 2.56 µM, respectively. Moreover, molecular docking analysis demonstrated the potential of these compounds to inhibit NA enzymes, revealing specific interactions between the compounds and target proteins. Full article

(This article belongs to the Special Issue Marine Microorganisms Bioprospecting, 2nd Edition)

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12 pages, 2222 KB

Open AccessArticle

Biodiversity of Rhizosphere Fungi from Suaeda glauca in the Yellow River Delta and Their Agricultural Antifungal and Herbicidal Potentials

by Tian-Li Qu, Hong Li, Dong-Fang Cao, Meng-Ya Li, Chen Zhao, Li-Yuan Zhang, Bao-Hua Zhang, Lin Xiao and Feng-Yu Du

Mar. Drugs 2025, 23(12), 460; https://doi.org/10.3390/md23120460 - 29 Nov 2025

Cited by 1 | Viewed by 618

Abstract

Suaeda glauca is a typical halophyte distributed in coastal and inland zones of the Yellow River Delta. Its rhizosphere soil is a potential source for exploring various fungi and their metabolites. In this study, the rhizosphere fungal community of S. glauca was evaluated with high-throughput sequencing, suggesting that it was tightly associated with seasonal variation and soil physicochemical factors. The fungal diversity at the genus level when sampling in May was better than that in July and October. The physicochemical factors TK and TP exerted relatively positive effects on the fungal diversity, while SOM, pH and TDS exhibited negative ones. Using the dilution plating method, 55 cultivable fungal strains were further isolated from the rhizosphere soil of S. glauca, in which Aspergillus and Penicillium were the dominant ones. A total of 47 and 20 strains showed antifungal and herbicidal activity, respectively. Finally, bioassay-guided isolation from the representative strain A. tabacinus GD-25 obtained three polyketides (1–3) and one diphenyl ether (4). 1 (sydonic acid) and 4 (diorcinol) greatly inhibited mycelial vitality of Bortrytis cinerea, with IC₅₀ values of 75.4 and 67.4 mg/L, respectively. In addition, 50 μg/mL of 4 could almost inhibit seedling growth of Echinochloa crusgalli. Full article

(This article belongs to the Special Issue Marine Microorganisms Bioprospecting, 2nd Edition)

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