Enzyme Inhibitors from Marine Resources, 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1145

Special Issue Editors


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Guest Editor
Institute for Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Campus Universitari, Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain
Interests: proteolytic enzymes and inhibitors; natural/synthetic inhibitors and ligands; structure-function; proteomics; molecular imaging; drug-discovery and screening
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Guest Editor
Centre for Protein Studies, Faculty of Biology, University of Havana, Cuba, calle 25, Nº 455 (Vedado), La Habana, Cuba
Interests: aminopeptidases and inhibitors; natural and synthetic inhibitors; cancer; malaria; drug-discovery and screening
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine living organisms and their main and secondary compounds and metabolites are among the richest in biological diversity. Many of their fundamental qualities and applications are still fully or partially unexplored. Since enzymes are essential in the plethora of biological functions of these organisms, it is understood that enzyme inhibitors are also involved in the control of these functions, as well as in many diseases and attack–defense processes. Research on the natural inhibitors found in marine organisms is, therefore, currently of great interest in a myriad of research perspectives.

In light of the success of the Special Issue “Enzyme Inhibitors from Marine Resources ” (https://www.mdpi.com/journal/marinedrugs/special_issues/Marine_Enzyme_Inhibitors), we are pleased to announce the 2nd edition.

The Special Issue intends to collect novel research on non-peptide or peptide/protein inhibitors, or derived forms, with a focus on the isolation, structure–function characterization, method of action, variety, evolution, screening, genomics–proteomics, and classification of marine enzyme inhibitors. Additionally, we wish to document their behavior in normal, diseased, and perturbed (i.e., extreme or stressed) conditions, as well as in attack–defense states and the interrelationships among organisms. Related research on organisms from large vertebrates and algae to small invertebrates and microorganisms is encouraged. Additionally, studies on the potential value of such molecules for biological, biotechnological, and pharmaceutical/biomedical uses, particularly as drugs or lead compounds against microbial, viral, parasitic, inflammatory, cardiovascular, and oncological diseases, are welcome. Reviews on successes and central issues will also be acknowledged.

Prof. Dr. Francesc Xavier Avilés
Prof. Dr. Isel Pascual Alonso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine inhibitors of enzymes
  • non-peptide and peptide/protein inhibitors
  • isolation and characterization
  • structure-function
  • genomics and proteomics
  • variety and evolution
  • biological role
  • biotechnology
  • drug screening and discovery
  • imaging and nano-technology
  • potential for therapeutics

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Published Papers (1 paper)

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Research

23 pages, 12666 KiB  
Article
Preparation of Acetylcholinesterase Inhibitory Peptides from Yellowfin Tuna Pancreas Using Moderate Ultrasound-Assisted Enzymatic Hydrolysis
by Pai Peng, Hui Yu, Meiting Xian, Caiye Qu, Zhiqiang Guo, Shuyi Li, Zhenzhou Zhu and Juan Xiao
Mar. Drugs 2025, 23(2), 75; https://doi.org/10.3390/md23020075 - 9 Feb 2025
Viewed by 1006
Abstract
Bioactive peptides represent a promising therapeutic approach for Alzheimer’s disease (AD) by maintaining cholinergic system homeostasis through the inhibition of acetylcholinesterase (AChE) activity. This study focused on extracting AChE inhibitory peptides from yellowfin tuna pancreas using moderate ultrasound-assisted enzymatic hydrolysis (MUE). Firstly, papain [...] Read more.
Bioactive peptides represent a promising therapeutic approach for Alzheimer’s disease (AD) by maintaining cholinergic system homeostasis through the inhibition of acetylcholinesterase (AChE) activity. This study focused on extracting AChE inhibitory peptides from yellowfin tuna pancreas using moderate ultrasound-assisted enzymatic hydrolysis (MUE). Firstly, papain and MUE stood out from five enzymes and four enzymatic hydrolysis methods, respectively, by comparing the degree of hydrolysis and AChE inhibitory activity of different pancreatic protein hydrolysates. Subsequently, the optimal MUE conditions were obtained by single-factor, Plackett–Burman, and response surface methodologies. The pancreatic protein hydrolysate prepared under optimal MUE conditions was then purified by ultrafiltration followed by RP-HPLC, from which a novel AChE inhibitory peptide (LLDF) was identified by LC-MS/MS and virtual screening. LLDF effectively inhibited AChE activity by a competitive inhibition mechanism, with an IC50 of 18.44 ± 0.24 μM. Molecular docking and molecular dynamic simulation revealed that LLDF bound robustly to the active site of AChE via hydrogen bonds. These findings provided a theoretical basis for the valuable use of yellowfin tuna pancreas and introduced a new viewpoint on the potential therapeutic advantages of AChE inhibitory peptides for future AD treatment. Full article
(This article belongs to the Special Issue Enzyme Inhibitors from Marine Resources, 2nd Edition)
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