Molecular Metabolisms and Regulations of Marine Algae

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Chemoecology for Drug Discovery".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 387

Special Issue Editors


E-Mail Website
Guest Editor
Fisheries College, Jimei University, Xiamen 361021, China
Interests: macroalgae; adaption; genetic breeding; omics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China
2. Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China
Interests: seaweed; adaption; omics; development; regulation
CAS and Shandong Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Interests: microalgae; metabolic regulation; gene editing; synthetic biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Exploring the metabolic pathways and regulatory mechanisms of intracellular biomolecules (such as nucleic acids, proteins, and metabolites) in marine algae contributes to the identification of important/specific metabolic pathways and key enzymes in algae, as well as to understanding their adaptability to extreme environmental conditions. By regulating molecular metabolic pathways, it is possible to enhance the yield, stress resistance, and quality of economically valuable algae, and to optimize the production of bioactive substances.

The main research directions of the Special Issue include the following:

1. Analysis of Metabolic Pathways
The study of the processes of synthesis and degradation of substances within marine algal cells, revealing the interactions between different metabolic pathways and their regulatory networks.

2. Research on Key Enzymes and Regulatory Factors
Investigations of the catalytic activity and substrate specificity of metabolic enzymes and their relationships with metabolic pathways; analysis of the regulatory roles of transcription factors, non-coding RNAs, and other elements within metabolic networks.

3. Mechanisms of Metabolic Regulation
Exploration of the coupling mechanisms between metabolism and environmental factors, such as how hormones, nutrients, and abiotic stresses regulate metabolic pathways; study of the feedback inhibition or promotion effects of metabolic products on their pathways.

4. Application of Multi-Omics Technologies in Marine Algal Metabolism Research
The utilization of high-throughput sequencing technologies, including genomics, transcriptomics, and metabolomics, to identify metabolic gene clusters, elucidate the biosynthesis pathways of marine algal metabolites, and analyze metabolic pathways.

5. Metabolic Engineering and Regulatory Applications
The employment of genetic engineering technologies to regulate key metabolic genes in algal cells; the construction of stable and efficient metabolic networks to enhance the production and yield of active algal metabolites; the application of the “DBLD” concept and efficiency evaluation for metabolite production.

Dr. Wenlei Wang
Dr. Haimin Chen
Dr. Wenhui Gu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine algae
  • molecular metabolisms
  • genetic regulations
  • multi-omics
  • metabolic engineering
  • gene editing
  • applications

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Published Papers (1 paper)

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Research

22 pages, 2824 KiB  
Article
Metabolic Responses of Pyropia haitanensis to Dehydration-Rehydration Cycles Revealed by Metabolomics
by Jian Wen, Jianzhi Shi, Muhan Meng, Kai Xu, Yan Xu, Dehua Ji, Wenlei Wang and Chaotian Xie
Mar. Drugs 2025, 23(5), 203; https://doi.org/10.3390/md23050203 - 8 May 2025
Viewed by 299
Abstract
Pyropia haitanensis (T.J. Chang and B.F. Zheng) undergoes periodic dehydration and rehydration cycles, necessitating robust adaptive mechanisms. Despite extensive research on its physiological responses to desiccation stress, the comprehensive metabolic pathways and recovery mechanisms post-rehydration remain poorly understood. This study investigated the metabolic [...] Read more.
Pyropia haitanensis (T.J. Chang and B.F. Zheng) undergoes periodic dehydration and rehydration cycles, necessitating robust adaptive mechanisms. Despite extensive research on its physiological responses to desiccation stress, the comprehensive metabolic pathways and recovery mechanisms post-rehydration remain poorly understood. This study investigated the metabolic responses of P. haitanensis to varying degrees of desiccation stress using LC-MS and UPLC-MS/MS. Under mild dehydration, the thallus primarily accumulated sugars and proline, while moderate and severe dehydration triggered the accumulation of additional osmoprotectants like alanine betaine and trehalose to maintain turgor pressure and water retention. Concurrently, the alga activated a potent antioxidant system, including enzymes and non-enzymatic antioxidants, to counteract the increased reactive oxygen species levels and prevent oxidative damage. Hormonal regulation also plays a crucial role in stress adaptation, with salicylic acid and jasmonic acid upregulating under mild dehydration and cytokinins and gibberellin GA15 accumulating under severe stress. Rehydration triggered the recovery process, with indole acetic acid, abscisic acid, and jasmonic acid promoting rapid cell recovery. Additionally, arachidonic acid, acting as a signaling molecule, induced general stress resistance, facilitating the adaptation of the thallus to the dynamic intertidal environment. These findings reveal P. haitanensis’ metabolic adaptation strategies in intertidal environments, with implications for enhancing cultivation and stress resistance in this economically important seaweed. Full article
(This article belongs to the Special Issue Molecular Metabolisms and Regulations of Marine Algae)
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