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Marine Extremophiles and Their Metabolites

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 190

Special Issue Editor


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Guest Editor
School of Medicine and Pharmacy, Ocean University of China, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
Interests: marine extremophiles; biosynthesis; secondary metabolite

Special Issue Information

Dear Colleagues,

Marine extremophiles refer to microorganisms that thrive in extreme marine environments, such as hydrothermal vents, cold seeps, deep ocean abysses, submarine salt lakes, polar seas, and other conditions including extremely low temperatures, high pressures, high salinity, low oxygen levels, high radiation, and high acidity or alkalinity. These unique environments pose significant challenges to life, yet marine extremophiles have evolved unique physiological mechanisms to adapt to and flourish in such conditions.

The study of marine extremophiles and their metabolites holds immense significance. These microorganisms also produce a wide range of unique enzymes and bioactive compounds that have potential applications. The study of marine extremophiles' metabolites can provide insights into the biochemical pathways and mechanisms that enable these organisms to survive in extreme conditions. These results can be leveraged to develop novel biotechnological processes and products that can be used as bioremediation, pharmaceuticals, and biotechnology.

This Special Issue aims to collect papers on the most recent findings or comprehensive review papers in the field of “Marine Extremophiles and their metabolites”.

Prof. Dr. Yi Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine extremophiles
  • natural products
  • enzymes
  • biosynthesis
  • structure elucidation
  • genome mining
  • bioprospecting

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Published Papers (1 paper)

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Research

12 pages, 1513 KB  
Article
Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Halomonas Strain
by Yunchen Yan, Zhiting Li, Hongcheng Li, Junpeng Sun, Wenli Li and Fei Xiao
Mar. Drugs 2026, 24(1), 16; https://doi.org/10.3390/md24010016 (registering DOI) - 26 Dec 2025
Abstract
Mining bioactive secondary metabolites from microorganisms originating from deep-sea cold seep holds significant potential for discovering novel drug lead compounds. In this study, three known indole derivatives (13) were isolated from cold-seep-derived Halomonas meridiana OUCLQ22-B7. Subsequently, two-new indole dimers, [...] Read more.
Mining bioactive secondary metabolites from microorganisms originating from deep-sea cold seep holds significant potential for discovering novel drug lead compounds. In this study, three known indole derivatives (13) were isolated from cold-seep-derived Halomonas meridiana OUCLQ22-B7. Subsequently, two-new indole dimers, meribisindole A (4) and meribisindole B (5), with nine known metabolites (614) were obtained via indole precursor feeding strategy. The structure of these compounds was elucidated via a combination of spectroscopic methods and circular dichroism (CD) measurement. Antimicrobial assays revealed that compounds 4, 7 and 8 exhibited potent inhibitory activity against Fusarium oxysporum CICC 41029 with minimal inhibitory concentrations (MICs) of 0.39−12.5 μg/mL, and compound 11 showed significant growth inhibition against Staphylococcus aureus CCARM 3090 with MIC value at 0.098 μg/mL. Full article
(This article belongs to the Special Issue Marine Extremophiles and Their Metabolites)
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