Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
5.4
Journals
Marine Drugs
Special Issues
Marine Antioxidant Peptides: Purification, Identification and Potential Health Benefits
share announcement

Marine Antioxidant Peptides: Purification, Identification and Potential Health Benefits

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 2908

Special Issue Editor

Prof. Dr. Jae-Young Je

E-Mail Website
Guest Editor
Major of Human Bioconvergence, Division of Smart Healthcare, Pukyong National University, Busan, Republic of Korea
Interests: bioactive peptides; chitosan; polyphenols; nutraceuticals; functional foods

Special Issue Information

Dear Colleagues,

Marine bioresources are a good source for bioactive compounds due to their unique environment. Antioxidant peptides are recognized as key bioactive compounds from marine bioresources. They can be extracted by several ways and are identified mainly by chromatography and spectroscopic techniques. Accumulating evidence suggests that marine antioxidant peptides with a unique structure show versatile biological activities with a potential health promoting effect. Although many antioxidant peptides are purified and identified from marine bioresources, there is a lack of comprehensive understanding of the health benefits offered by them. It is believed that antioxidant peptides play multiple health promoting functions. Thus, it is a great challenge to uncover the exact role that renders these promoting effects. This Special Issue aims to promote research in the field and to update recent advanced knowledge on marine antioxidant peptides.

Prof. Dr. Jae-Young Je
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine organisms
  • Enzymatic hydrolysis
  • Antioxidant activity
  • Disease
  • Health Benefits
  • Functional food
  • Pharmaceuticals
  • Nutraceuticals

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 24887 KiB  
Article
Cytoprotective Role of Edible Seahorse (Hippocampus abdominalis)-Derived Peptides in H2O2-Induced Oxidative Stress in Human Umbilical Vein Endothelial Cells
by Yunok Oh, Chang-Bum Ahn and Jae-Young Je
Mar. Drugs 2021, 19(2), 86; https://doi.org/10.3390/md19020086 - 03 Feb 2021
Cited by 21 | Viewed by 2502
Abstract
Oxidative stress-induced endothelial dysfunction is strongly linked to the pathogenesis of cardiovascular diseases. A previous study revealed that seahorse hydrolysates ameliorated oxidative stress-mediated human umbilical vein endothelial cells (HUVECs) injury. However, the responsible compounds have not yet been identified. This study aimed to [...] Read more.
Oxidative stress-induced endothelial dysfunction is strongly linked to the pathogenesis of cardiovascular diseases. A previous study revealed that seahorse hydrolysates ameliorated oxidative stress-mediated human umbilical vein endothelial cells (HUVECs) injury. However, the responsible compounds have not yet been identified. This study aimed to identify cytoprotective peptides and to investigate the molecular mechanism underlying the cytoprotective role in H2O2-induced HUVECs injury. After purification by gel filtration and HPLC, two peptides were sequenced by liquid chromatography-tandem mass spectrometry as HGSH (436.43 Da) and KGPSW (573.65 Da). The synthesized peptides and their combination (1:1 ratio) showed significant HUVECs protection effect at 100 μg/mL against H2O2-induced oxidative damage via significantly reducing intracellular reactive oxygen species (ROS). Two peptides and their combination treatment resulted in the increased heme oxygenase-1 (HO-1), a phase II detoxifying enzyme, through the activation of nuclear transcription factor-erythroid 2-related factor (Nrf2). Additionally, cell cycle and nuclear staining analysis revealed that two peptides and their combination significantly protected H2O2-induced cell death through antiapoptotic action. Two peptides and their combination treatment led to inhibit the expression of proapoptotic Bax, the release of cytochrome C into the cytosol, the activation of caspase 3 by H2O2 treatment in HUVECs, whereas antiapoptotic Bcl-2 expression was increased with concomitant downregulation of Bax/Bcl-2 ratio. Taken together, these results suggest that seahorse-derived peptides may be a promising agent for oxidative stress-related cardiovascular diseases. Full article
(This article belongs to the Special Issue Marine Antioxidant Peptides: Purification, Identification and Potential Health Benefits)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop