Immunological and Antimicrobial Adjuvants from Marine Sources
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (5 February 2021) | Viewed by 5484
Special Issue Editor
Interests: structure and function of biological membranes; lipids; phase transitons; marine hydrobionts; bacteria; adaptation; antibiotic resistance; lipid-dependent conformation and functions of proteins; lipochaperoning; vaccines; adjuvant vehicles; recombinant proteins; viruses; nanobiotechnology; immunology
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Special Issue Information
Dear Colleagues,
The protection of macroorganisms (humans and animals) from pathogenic microorganisms depends both on the state of the macroorganism's immune system and on the sensitivity of microorganisms to antibiotics. To increase the effectiveness of the corresponding mechanisms, immunological and antimicrobial adjuvants are used, respectively.
Immunological adjuvant is a substance or complex of substances, including adjuvant delivery systems, that is administered with an antigen to boost or modifies the immune response to that target antigen. Recently, there has been an active use of adjuvants in the immunotherapy of tumors, since cancer is associated with impaired functioning of the immune system.
An immunological adjuvant is a substance or complex of substances, including adjuvant delivery systems, which is administered with an antigen to boost (immunostimulation) and/or modulate (immunomodulation) the immune response to that target antigen. Immunological adjuvants differ in their effect on adaptive and innate immunity, which is actually associated with the involvement of T-cells responsible for recognizing antigen, B-lymphocytes, producing antibodies, and innate immunity cells. Recently, there has been an active use of adjuvants in the immunotherapy of tumors (Adjuvant immunotherapy for cancer), since cancer is associated with impaired functioning of the immune system.
On the other hand, increasing the effectiveness of vaccines can help to solve another global problem associated with a permanent widening list of pathogens resistant to antimicrobials. This problem primarily relates to antibiotic resistance of bacteria. Therefore, the use of adjuvants for antibiotics and other antimicrobial chemotherapeutic drugs is a new and one of the most effective strategies for restoring the sensitivity (resensitization) of pathogens to conventional antimicrobials. Antimicrobial adjuvants can directly act on the microbe and block the pathogen resistance to antimicrobials or enhance their effect by acting on the protective mechanisms of the macroorganism.
Marine organisms are abundant in biologically active substances. Some of them possess an adjuvant activity. The main goal of this Special Issue on “Marine-Derived Immunological and Antimicrobial Adjuvants” is to summarize the achievements in the field of the search for substances of marine origin and their semi-synthetic derivatives that possess adjuvant activity. Research articles and reviews devoted to mechanisms of actions of such adjuvants are also welcome.
Dr. Nina M. Sanina
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
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